Anti-hypertensive drugs

Question 1

First line drugs for hypertensino

Answer 1

diuretics, CCBs, ACEi, ARBs

Question 2

NIfedipine class and MOA

Answer 2

CCB: dihydropyridine…dilates vascular smooth muscle

Question 3

Nifedipine AE

Answer 3

acute tachycardia, peripheral edema

Question 4

Clonidine class and MOA

Answer 4

sympatholytic drug, centrally acting… reducing sympathetic outflow from CNS

Question 5

Clonidine AE

Answer 5

sedation, dry mough, dermatitis

Question 6

Methyldopa class and MOA

Answer 6

same as clonidine central acting sympatholytic drug

note: USED IN PREGNANCY

Question 7

Reserpine class and MOA

Answer 7

indirect acting adrenergic blocking agent… stoping vesicular storage
note: normally combined with diuretics

Question 8

Reserpine AE

Answer 8

depression, nasal congestion

Question 9

Phenoxybenamein class and indication

Answer 9

non selective a blocker…used in pheochromocytoma

Question 10

Pehenoxybenazmine AE

Answer 10

tachycardia

Question 11

Prazosin class

Answer 11

selective a1 antagonist

Question 12

prazosin substitutes

Answer 12

terazosin, doxasosin

have longer half lives

Question 13

prazosin AE

Answer 13

hypotension

Question 14

nonselective BB

Answer 14

propranolol, nadolol, pindolol

Question 15

selective BB

Answer 15

Esmolol, metoprolol, atenolol

Question 16

BB with alpha activitiy

Answer 16

Labetolol, and carvedilol

Question 17

BB contraindications

Answer 17

Cardio shock, bradycardia, asthma, hf, also masks hypoglycemia in diabetics

Question 18

minoxidil

Answer 18

vasodilator

Question 19

other vasodilators

Answer 19

hydralazine, nitroprusside

both for emergencies

Question 20

ACEi drugs

Answer 20

captopril (short 1/2)
elanapril
Lisinopril (1 day dosing)

Question 21

Acei AE

Answer 21

hyperkalemia, dry cough, angioedema

contra: pregnancy bilateral renal stenosis

Question 22

Losartan class ad MOR

Answer 22

ARB

Question 23

Losartan AE

Answer 23

hyperkalemia

contra in PREGNANCY