Nitrates, Hydral,Minoxidil

Question 1

MOA of Hydralazine?

Answer 1

MOA is not completely understood. Vasodilate arterial vessels.

Question 2

MOA of Minoxidil

Answer 2

Potassium channel stimulant causing vasodilation.

Question 3

Side effects of Minoxidil

Answer 3

Side Effects: Fluid retention, tachycardia, hypertrichosis (used to treat male pattern baldness)

Question 4

Contraindications of Nitrates

Answer 4

Contraindicated:
Vasodilation can result in increased intracranial pressure so nitrates are contraindicated in head trauma or cerebral hemorrhage.
No pregnancy usage

Question 5

Nitrates MOA

Answer 5

Nitroglycerin (NTG) and its analogues act largely by providing more nitric oxide (NO) to vascular endothelium and arterial smooth muscle, resulting in vasodilation

Question 6

Nitrates we need to know

Answer 6

Nitro and Isosorbide

Question 7

Black box warning for Minoxidil

Answer 7

May cause pericardial effusion and occasionally progressing to tamponade. May exacerbate angina pectoris.

Question 8

The SNS stimulation and sodium and water retention problems associated with both Hydral and Minoxidil require

Answer 8

the concurrent administration of a BB and a loop diuretic.