Alpha2Agonists Flashcards
MOA clonidine
Binds to presynaptic terminal Alpha2Receptors, which inhibits Norepi from being released into the synaptic cleft - creating a decrease in sympathetic outflow.
What drug class is Clonidine and Methyldopa
Alpha 2 Agonists - centrally acting
Can Clonidine and Methyldopa (Alpha 2 Agonists) be used with diuretics? Why?
Yes. they can be used with diuretics because MOA can concurrently increase serum sodium levels.
MOA methyldopa
Same end effect as clonidine. But it inhibits norepi production before packaged into presynaptic vesicles.
Are Clonidine and Methyldopa first line antihytn meds
no. 2nd/3rd line
How should a patient stop taking Clonidine or Methyldopa? Why?
Gradually taper dose - do NOT abruptly stop - can cause severe rebound HTN
What patients need to be careful with Methyldopa use?
Methyldopa metabolites will accumulate and cause prolonged hypotension in patients with renal failure.
Which can be used in pregnant people: Clonidine or Methyldopa
Methyldopa first line for pregnant patients
Clonidine is contraindicated in pregnancy
Clonidine is most often used for which patients?
Pts going through depressant drug withdrawal (etoh, benzos, opioids) who are experiencing tachycardia and hypertension.
clonidine should not be taken with CNS depressants because?
additive sedation effects
Two common side effects of both Methyldopa and Clonidine
Dry Mouth and Pruritic Rash
Off brand use for clonidine?
ADHD medication in kids/teens
What forms can clonidine be administered
pill or patch
What is a Coombs test? What drug requires one before starting it.
Blood test that detects antibodies on RBCs. Methyldopa
