Nicotinic/ AchE Inhibitors/ Botox Flashcards
Varenicline MOA: SOA: Use: Side effects:
Selective partial agonist at the a4/b2 Nn
SOA: CNS
Used for smoking cessation / avoiding withdrawal feeling
Suicidal, depression
It out competes nicotine for the Nn receptor and partially activates it
Verenicline
Succinylcholine MOA SOA USE SIDE EFFECT
- Depolarizing agonist at the Nn receptors, opens all channels
- NMJ
- Paralysis
- Increased IOP, and hypertension and arrhythmia
Curare(curium)
MOA
SOA
USE
SIDE EFFECT
- competitive antagonist = non depolarizing
Block nicotinic receptors preventing ACh from binding
-NMJ
-Paralysis
-histamine release causes bronchial spasms & hypotension
ENDROPHONIUM
MOA
USE
AchE inhibitor reversible
Diagnosis of myasthenia gravis
Physostigmine
MOA
SOA
USE
AchE inhibitor, reversible
CNS
Treatment of poisoning of anti muscarinic (atropine)
Pyridostigmine
MOA
SOA
USE
Ache inhibitor,reversible
Does not cross BBB
Tx Myastenia Gravis
Neostigmine
MOA
SOA
USE
Ache inhibitor,reversible
Does not cross BBB
Tx Myastenia Gravis
Rivastigmine MOA SOA USE SIDE EFFECT
AchE inhibitor, reversible Causes Ach increase in the brain Brain Slows down Alzheimer’s progression Dumbbells if it crosses BBB Dumbells (except emesis + CNS stimulation) if it doesnt
Donepezil MOA SOA USE SIDE EFFECT
AchE inhibitor, reversible Causes Ach increase in the brain Brain Slows down Alzheimer’s progression Dumbbells if it crosses BBB Dumbells (except emesis + CNS stimulation) if it doesnt
Whats an agonist to the Nn receptor at the NMJ?
Acetylcholine
And succinylcholine
Exception of curonium drugs
Pan uranium because it cant get to the ganglia and block Nm
Which dug produces paralysis by blocking the ability of Ach to bind and activate the Nm receptors?
Curonium
Which drugs can reverse the effects of curare?
Curare causes paralysis
Any AChe inhibitor can reverse action
STIGMINE drugs
STIGMINE drugs cause dumbbells or anti dumbbells? And why
Dumbells because they are AchE inhibitors which cause increase of ACh
Ach= dumbbells
Organophosphates
MOA
USES
SIDE EFFECT
Ache irreversible inhibitor
Insecticides
Crazy dumbells
Echothiophate
MOA
SOA
USE
SIDE EFFECT
AChE inhibitor, reversible (organophosphate inhibitor)
Increases Ach-> increasing aqueous humor outflow
Tx glaucoma/ lower IOP
Blurry vision and miosis
Botulism Toxin
MOA
SOA
USE
Prevents Ach from being released from presynaptic cleft
Breaks down SNARE proteins not allowing Ach to be released
Skin
Relax facial wrinkles/drooling/migraines
STIGMINE drugs all are
AChE inhibitors
STIGMINE drug that treats Alzheimer’s
Rivastigmine
Stigmine drug that treats myasthenia gravis
Pyridostigmine
If a drug is an antagonist to the Nm receptors, what would be most likely effects
Paralysis
And decrease HR
