Adrenergic

Question 1

Solifenacin is an ____ and causes

Answer 1

Muscarinic antagonist and causes anti dumbells

Question 2

Which drug should not be given with nitroglycerin because of possible marked hypotension

Answer 2

Sidenafil (any with afil)

Question 3

Drug is an alpha 1 selective agonist, causes VC,activated Gq, increases Ca++ in smooth muscle

Answer 3

Phenylephrine

Question 4

What receptors affect aqueous outflow

Answer 4

muscarinic and betas

Question 5

Alpha 2 & beta 1 receptors in the eye effect aqueous humor production how?

Answer 5

A2->Gi=decrease aqueous humor production

B->Gs= increase aqueous humor production

Question 6

Can decrease HR by suppressing the SNS

Answer 6

Clonidine

Question 7

Alpha 1 effect on the body

Answer 7

I think, I see & smell bloody urine

brain stimulation, mydriasis, VC/hypertension, contraction of urethra (can’t pee)

Question 8

Alpha 1 antagonist effect on the body

Answer 8

Itis&sbu

sedation, miosis, VD/hypotension, urination

Question 9

Alpha 1 receptors are in what part of the body

Answer 9

The brain, eye, and blood vessels

Question 10

Phenylephrine/ephedrine (use in the eye) 
MOA 
SOA 
USES 
Side effects

Answer 10

Selective a1 agonist  
Local VC in the eye 
Dilation/ glaucoma tx/ relief of eye redness 
Decreases AH production 
I think i see & smell bloody urine

Question 11

-zoline

MOA
SOA
USE
SIDE EFFECTS

Answer 11

a1 & a2 non selective agonist
VC arteries in the conjunctiva and nasal mucosa
Relief of redness in the eye
Contraindicated with closed angle glaucoma

Question 12

Phenylephrine: how its used for nasal decongestant? And side effects?

Answer 12

VC of sinus BV rushes discharge
Increases after load and preload= hypertension & arrhythmias
Rebound congestion

Question 13

Prazosin
MOA 
SOA 
Use 
Side effect

Answer 13

Selective a1 antagonist
Cause anti I think I see& smell bloody urine (decrease after load and Venous resistance/tachycardia) blurred vision
PTSD: decrease nightmares

Question 14

a2 Adrenergic receptors are linked to (G protein pathway)

Answer 14

a2-> Gi -> inhibit AC-> inhibits CAMP

Question 15

Alpha 2 are located where

Answer 15

Nerve ending, small BV , eye

Question 16

Effect of alpha 2 on the body

Answer 16

A2-> Gi
Suppresses sympathetics
decreases HR, BP,CO NE release
Eye: decreases aqueous humor production

Question 17

Most likely to decrease HR by suppressing the SNS

Answer 17

(Clonidine)

A2 agonist

Question 18

Clonidine 
MOA 
SOA 
USE 
SIDE EFFECTS

Answer 18

Selective a 2 agonist
Pill :CNS/ inhibits aqueous humor production
Used to w ADHD medication to decrease dose of stimulant/systemic HTN
Suppress SNS: depression, nightmares
Constipation

Question 19

Apraclonidine difference to Clonidine

Answer 19

Also a selective a 2 agonist but doesnt cross BBB as much.

Used in the eye: decreases AH production

Question 20

Brimonidine

Answer 20

Just like Clonidine bout used in the eye to decrease aqueous humor production

Question 21

Why does clonidine cause constipation?

Answer 21

It activates a2-> Gi-> suppress Ach release -> doesnt act on M3

Question 22

Effect of dobutamine on the eye

Answer 22

Beta 1 agonist will increase AH production ( not affect blood flow)

Question 23

Pt OD with Epi which antagonist would you gove first

Answer 23

Alpha 1 antagonist