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Pharm Exam 2 > Cholinergics > Flashcards

Cholinergics Flashcards

1
Q

Beta blocker effect on the eye

A

Decrease production of aqueous humor

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2
Q

Muscarinic agonist

Muscarinic antagonist effect on the eye

A

Muscarinic agonist: constrict pupil (miosis)
Less volume of AH
Muscarinic antagonist: dilate pupil (mydriasis)
Occlude canal of schlemm raising IOP

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3
Q

Major receptor subtype in the eye ____. Pathway of what effect it would have on the eye ___.

A

M3 -> Gq-> ca+ -> miosis

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4
Q

M3 antagonist will cause what effect on the eye

A

Mydriasis

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5
Q

M1 & M3 bind to what Gprotein causing what? (Pathway and effect on body)

A

Gq-> activates PLC-> increases IP3 & Ca+

Dumbells except bradycardia

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6
Q

M2 bind to what Gprotein causing what? (Pathway and effect on body)

A

Gi-> inhibit AC-> decrease Camp

Only heart) decreases HR (bradycardia

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7
Q

Drugs with CHOL

A

Muscarinic agonist
Cholinergic system
NON SELECTIVE AND REVERSIBLE
Effect is dumbells

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8
Q

Carbachol is _____ to _____ receptors

A

Non selective agonist to the muscarinic receptors

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9
Q

Depolarizing agonists

A

Acetylcholine

Succinylcholine

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10
Q

Antagonists to Nm

A

Curare drugs

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11
Q

Blocks release of Ach

A

BOTOX

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12
Q

All drugs with TROP are ____ causing ____.

A

Non selective muscarinic antagonist
Reversible
Anti dumbells

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13
Q

Muscarinic antagonist effect on the eye

A

Mydriasis and decrease of aqueous outflow

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14
Q

IRREVERSIBLE ANTAGONIST TO THE ACHE

A

Organophosphates

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15
Q

Why dont we use atropine to dilate pts pupils?

A

Short duration of action

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16
Q

How can muscarinic antagonist treat respiratory disorders?

A

Treat COPD by causing bronchodilation

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17
Q

Which muscarinic antagonist drugs are less likely to have CNS effects?

A

The ones only bonding to M3s

Solifenacin, darifenacin, trospium

18
Q 
Pt exposed to Organophosphates, which will help with symptoms? 
Neostigmine 
Succinylcholine 
Rocuronium 
Atropine
A

Atropine

19
Q

Nitric oxide will helps heart conditions by

A

Vasodilation
Nitroglycerin
Nitroprusside
Isosorbide dinitrate

20
Q

M1 receptors are located where? Linked to?Causing?

A

In the brain
Linked to Gq
Causing dumbells

21
Q

M2 receptors are where? Linked to ? Causing ?

A

In the heart
Linked to Gi
Bradycardia

22
Q

M3 receptors are located where? Linked to ? Causing?

A

In all other organs (eye)
Gq
Dumbells

23
Q 
Pilocarpine 
MOA 
SOA
USES 
SIDE EFFECTS
A 
MOA : non selective muscarinic agonist, reversible 
SOA: eyes 
Uses: glaucoma treatment 
Side effects: dumbells  
Miosis
24
Q

Muscarinic antagonists used in the eye are ___? And causes ?

A 
Atropine 
Tropicamide 
Homatropine 
Cyclopentolate 
Causes pupil dilation
25
Q

Muscarinic antagonist that are used for COPDds for bronchodilation

A

(Ipatrop,tiotrop,clidinium)
Ipratropium
Tiotropium
aclidinium & umeclidinium

26
Q

Muscarinic antagonist that can treat COPD and have high affinity for M3

A

Aclidinium & umeclidinium

27
Q

What muscarinic antagonist is selective to M1 & M3

A

Triotropium

28
Q

Muscarinic antagonists that help with overactive bladder

A 
Oxybutynin 
Trospium 
Solifenacin
 darifenacin 
Tolderodine 
Fesoterodine
29
Q

Which muscarinic antagonists are M3 selective

A

Derifenacin
Solifenacin
Trospium

30
Q

Scopolamine
MOA:
SOA:
USES:

A

Muscarinic antagonist
Penetrates CNS rapidly
Tx motion sickness

31
Q 
Benztropine 
MOA
SOA 
USES 
SIDE EFFECTS
A

Non selective muscarinic antagonist
Blocks M1s
Tx Parkinson’s pts tx with L-dopa
Anti dumbells

32
Q

All of the CHOL drugs
MOA
SOA
USES

A

Non selective muscarinic agonist , reversible

Dumbells

33
Q

used to tx sjrogrens syndrome, glaucoma , xerostomia

A

Muscarinic agonists

Pilocarpine & cevimeline

34
Q

Beta blockers _____ aqueous humor

A

Decrease production

35
Q

Muscarinic agonist effect on eyes

A

Contract circular fibers
Accommodate for near vision
Improve drainage

36
Q

Muscarinic antagonist effects in the eye

A

Dilate pupil

Occlude canal raises IOP

37
Q

Major effects of M1

A

CNS excitation

38
Q

Major effects of M2

A

Bradycardia

39
Q

Major effect for M3

A

Dumbells

40
Q

Ach can interact with nicotinic receptors in a number of body regions except

A

Arterial smooth muscle

41
Q

Drugs that would be unsafe to take with nitrate ___. And why?

A

Afil

Because of unsafe drop ion BP causing severe hypotension ( too much VD)

Pharm Exam 2 (7 decks)

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