Cholinergics Flashcards
Beta blocker effect on the eye
Decrease production of aqueous humor
Muscarinic agonist
Muscarinic antagonist effect on the eye
Muscarinic agonist: constrict pupil (miosis)
Less volume of AH
Muscarinic antagonist: dilate pupil (mydriasis)
Occlude canal of schlemm raising IOP
Major receptor subtype in the eye ____. Pathway of what effect it would have on the eye ___.
M3 -> Gq-> ca+ -> miosis
M3 antagonist will cause what effect on the eye
Mydriasis
M1 & M3 bind to what Gprotein causing what? (Pathway and effect on body)
Gq-> activates PLC-> increases IP3 & Ca+
Dumbells except bradycardia
M2 bind to what Gprotein causing what? (Pathway and effect on body)
Gi-> inhibit AC-> decrease Camp
Only heart) decreases HR (bradycardia
Drugs with CHOL
Muscarinic agonist
Cholinergic system
NON SELECTIVE AND REVERSIBLE
Effect is dumbells
Carbachol is _____ to _____ receptors
Non selective agonist to the muscarinic receptors
Depolarizing agonists
Acetylcholine
Succinylcholine
Antagonists to Nm
Curare drugs
Blocks release of Ach
BOTOX
All drugs with TROP are ____ causing ____.
Non selective muscarinic antagonist
Reversible
Anti dumbells
Muscarinic antagonist effect on the eye
Mydriasis and decrease of aqueous outflow
IRREVERSIBLE ANTAGONIST TO THE ACHE
Organophosphates
Why dont we use atropine to dilate pts pupils?
Short duration of action
How can muscarinic antagonist treat respiratory disorders?
Treat COPD by causing bronchodilation
Which muscarinic antagonist drugs are less likely to have CNS effects?
The ones only bonding to M3s
Solifenacin, darifenacin, trospium
Pt exposed to Organophosphates, which will help with symptoms? Neostigmine Succinylcholine Rocuronium Atropine
Atropine
Nitric oxide will helps heart conditions by
Vasodilation
Nitroglycerin
Nitroprusside
Isosorbide dinitrate
M1 receptors are located where? Linked to?Causing?
In the brain
Linked to Gq
Causing dumbells
M2 receptors are where? Linked to ? Causing ?
In the heart
Linked to Gi
Bradycardia
M3 receptors are located where? Linked to ? Causing?
In all other organs (eye)
Gq
Dumbells
Pilocarpine MOA SOA USES SIDE EFFECTS
MOA : non selective muscarinic agonist, reversible SOA: eyes Uses: glaucoma treatment Side effects: dumbells Miosis
Muscarinic antagonists used in the eye are ___? And causes ?
Atropine Tropicamide Homatropine Cyclopentolate Causes pupil dilation
Muscarinic antagonist that are used for COPDds for bronchodilation
(Ipatrop,tiotrop,clidinium)
Ipratropium
Tiotropium
aclidinium & umeclidinium
Muscarinic antagonist that can treat COPD and have high affinity for M3
Aclidinium & umeclidinium
What muscarinic antagonist is selective to M1 & M3
Triotropium
Muscarinic antagonists that help with overactive bladder
Oxybutynin Trospium Solifenacin darifenacin Tolderodine Fesoterodine
Which muscarinic antagonists are M3 selective
Derifenacin
Solifenacin
Trospium
Scopolamine
MOA:
SOA:
USES:
Muscarinic antagonist
Penetrates CNS rapidly
Tx motion sickness
Benztropine MOA SOA USES SIDE EFFECTS
Non selective muscarinic antagonist
Blocks M1s
Tx Parkinson’s pts tx with L-dopa
Anti dumbells
All of the CHOL drugs
MOA
SOA
USES
Non selective muscarinic agonist , reversible
Dumbells
used to tx sjrogrens syndrome, glaucoma , xerostomia
Muscarinic agonists
Pilocarpine & cevimeline
Beta blockers _____ aqueous humor
Decrease production
Muscarinic agonist effect on eyes
Contract circular fibers
Accommodate for near vision
Improve drainage
Muscarinic antagonist effects in the eye
Dilate pupil
Occlude canal raises IOP
Major effects of M1
CNS excitation
Major effects of M2
Bradycardia
Major effect for M3
Dumbells
Ach can interact with nicotinic receptors in a number of body regions except
Arterial smooth muscle
Drugs that would be unsafe to take with nitrate ___. And why?
Afil
Because of unsafe drop ion BP causing severe hypotension ( too much VD)
