Cholinergics

Question 1

Beta blocker effect on the eye

Answer 1

Decrease production of aqueous humor

Question 2

Muscarinic agonist

Muscarinic antagonist effect on the eye

Answer 2

Muscarinic agonist: constrict pupil (miosis)
Less volume of AH
Muscarinic antagonist: dilate pupil (mydriasis)
Occlude canal of schlemm raising IOP

Question 3

Major receptor subtype in the eye ____. Pathway of what effect it would have on the eye ___.

Answer 3

M3 -> Gq-> ca+ -> miosis

Question 4

M3 antagonist will cause what effect on the eye

Answer 4

Mydriasis

Question 5

M1 & M3 bind to what Gprotein causing what? (Pathway and effect on body)

Answer 5

Gq-> activates PLC-> increases IP3 & Ca+

Dumbells except bradycardia

Question 6

M2 bind to what Gprotein causing what? (Pathway and effect on body)

Answer 6

Gi-> inhibit AC-> decrease Camp

Only heart) decreases HR (bradycardia

Question 7

Drugs with CHOL

Answer 7

Muscarinic agonist
Cholinergic system
NON SELECTIVE AND REVERSIBLE
Effect is dumbells

Question 8

Carbachol is _____ to _____ receptors

Answer 8

Non selective agonist to the muscarinic receptors

Question 9

Depolarizing agonists

Answer 9

Acetylcholine

Succinylcholine

Question 10

Antagonists to Nm

Answer 10

Curare drugs

Question 11

Blocks release of Ach

Answer 11

BOTOX

Question 12

All drugs with TROP are ____ causing ____.

Answer 12

Non selective muscarinic antagonist
Reversible
Anti dumbells

Question 13

Muscarinic antagonist effect on the eye

Answer 13

Mydriasis and decrease of aqueous outflow

Question 14

IRREVERSIBLE ANTAGONIST TO THE ACHE

Answer 14

Organophosphates

Question 15

Why dont we use atropine to dilate pts pupils?

Answer 15

Short duration of action

Question 16

How can muscarinic antagonist treat respiratory disorders?

Answer 16

Treat COPD by causing bronchodilation

Question 17

Which muscarinic antagonist drugs are less likely to have CNS effects?

Answer 17

The ones only bonding to M3s

Solifenacin, darifenacin, trospium

Question 18

Pt exposed to Organophosphates, which will help with symptoms? 
Neostigmine 
Succinylcholine 
Rocuronium 
Atropine

Answer 18

Atropine

Question 19

Nitric oxide will helps heart conditions by

Answer 19

Vasodilation
Nitroglycerin
Nitroprusside
Isosorbide dinitrate

Question 20

M1 receptors are located where? Linked to?Causing?

Answer 20

In the brain
Linked to Gq
Causing dumbells

Question 21

M2 receptors are where? Linked to ? Causing ?

Answer 21

In the heart
Linked to Gi
Bradycardia

Question 22

M3 receptors are located where? Linked to ? Causing?

Answer 22

In all other organs (eye)
Gq
Dumbells

Question 23

Pilocarpine 
MOA 
SOA
USES 
SIDE EFFECTS

Answer 23

MOA : non selective muscarinic agonist, reversible 
SOA: eyes 
Uses: glaucoma treatment 
Side effects: dumbells  
Miosis

Question 24

Muscarinic antagonists used in the eye are ___? And causes ?

Answer 24

Atropine 
Tropicamide 
Homatropine 
Cyclopentolate 
Causes pupil dilation

Question 25

Muscarinic antagonist that are used for COPDds for bronchodilation

Answer 25

(Ipatrop,tiotrop,clidinium) Ipratropium Tiotropium aclidinium & umeclidinium

Question 26

Muscarinic antagonist that can treat COPD and have high affinity for M3

Answer 26

Aclidinium & umeclidinium

Question 27

What muscarinic antagonist is selective to M1 & M3

Answer 27

Triotropium

Question 28

Muscarinic antagonists that help with overactive bladder

Answer 28

``` Oxybutynin Trospium Solifenacin darifenacin Tolderodine Fesoterodine ```

Question 29

Which muscarinic antagonists are M3 selective

Answer 29

Derifenacin Solifenacin Trospium

Question 30

Scopolamine MOA: SOA: USES:

Answer 30

Muscarinic antagonist Penetrates CNS rapidly Tx motion sickness

Question 31

``` Benztropine MOA SOA USES SIDE EFFECTS ```

Answer 31

Non selective muscarinic antagonist Blocks M1s Tx Parkinson’s pts tx with L-dopa Anti dumbells

Question 32

All of the CHOL drugs MOA SOA USES

Answer 32

Non selective muscarinic agonist , reversible Dumbells

Question 33

used to tx sjrogrens syndrome, glaucoma , xerostomia

Answer 33

Muscarinic agonists | Pilocarpine & cevimeline

Question 34

Beta blockers _____ aqueous humor

Answer 34

Decrease production

Question 35

Muscarinic agonist effect on eyes

Answer 35

Contract circular fibers Accommodate for near vision Improve drainage

Question 36

Muscarinic antagonist effects in the eye

Answer 36

Dilate pupil | Occlude canal raises IOP

Question 37

Major effects of M1

Answer 37

CNS excitation

Question 38

Major effects of M2

Answer 38

Bradycardia

Question 39

Major effect for M3

Answer 39

Dumbells

Question 40

Ach can interact with nicotinic receptors in a number of body regions except

Answer 40

Arterial smooth muscle

Question 41

Drugs that would be unsafe to take with nitrate ___. And why?

Answer 41

Afil | Because of unsafe drop ion BP causing severe hypotension ( too much VD)