Indirect Acting Adrenergic Flashcards
1
Q
3 types of indirect acting Adrenergic
A
Reuptake inhibitor
Enhance release of NE
Block breakdown of NE
2
Q
Cocaine MOA SOA USE Side effect
A
Reuptake inhibitor (indirect antagonist) Blocks NET = increases NE at the synapse
CNS
Used for mild surgery
Cerebral VC
3
Q
Amphetamine -phenidate -fetamine MOA SOA USE SIDE EFFECT
A
Adderall Enhance release of NE Brain Increase focus for ADHD Excess Excitation/ blurred vision/ accommodation problem
4
Q
What are MOA inhibitors? MAO A & MAO B ?
A
MOA usually break down NE. Inhibition would increase NE being releases
MAO A = gut
MAO B = brain
5
Q
Indirect acting adrenergics that will tx depression
A
Phenelzine & selegine/rasagiline ( MOA antagonist )
6
Q
Phenelzine MOA SOA USE SIDE EFFECTS
A
Non selective MOA irreversible antagonist (BLOCKS BREAKDOWN OF NE)
CNS
Tx depression/ Parkinson’s
Dietary tyramine (fermented foods cause hypertensive crisis )
7
Q
Selegiline / rasagiline
MOA
SOA
USE
A
Selective MAO B irreversible antagonist (block breakdown of NE)
CNS
Tx Depression
8
Q
Side effects of all indirect acting adrenergics
A
(Increase NE) CNS: insomnia, euphoria, psychosis CV: HTN, arrhythmia, Cerebral VC Endocrine: weight loss Loss of libido Blurred vision, mydriasis
