Nicotine/Smoking Cessation

Question 1

drugs that may have a decreased effect while smoking, due to induction of CYP1A2

Answer 1

caffeine, clozapine, fluvoxamine, olanzapine, tacrine, theophylline, bendamustine, warfarin

Question 2

drugs that have increased effect while smoking due to induction of CYP1A2

Answer 2

clopidogrel (prodrug)- converted to active metabolite

Question 3

what is the active metabolite of nicotine that cause negative effects

Answer 3

cotinine