Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Pharm > Nicole - Anti-Arrhythmetics > Flashcards

Nicole - Anti-Arrhythmetics Flashcards

1
Q

What are the anti-arrhythmetic Class 1 drugs?

A

Class 1: Sodium channel blockade

1a: prolong APD, intermediate dissociation kinetics
- Procainamide, Quinidine
1b: shorten APD ion selective tissues, rapid dissociation kinetics
- Lidocaine
1c: minimal APD impact, slow dissociation kinetics
- Flecainide

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What are the class 2 anti-arrhythmics?

A

Class 2: sympatholytic action (B blockers)

Propranolol

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What are the class 3 anti-arrhthmics?

A

Class 3: Prolongation of APD

Amiodarone

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What are the class 4 anti-arrhythmics?

A

Class 4: Blockade of cardiac calcium current

Varapamil
Diltiazem

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What is the MOA of Procainamide?

A
  • Decreases myocardial excitability and conduction velocity.
  • may depress myocardial contractility by increasing electrical stimulation threshold of ventricle
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Procainamide has the potential to cause what significant side effect?

A

SLE

Monitor ANA tigors

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

The indications for Procainamide?

A

Life threatening ventricular arrhythmias

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Lidocaine is in what class of anti-arrhytmics?

A
  • Class 1b
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Indications for Lidocaine?

A

Suppression of existing ventricular arrhythmias

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

MOA of Lidocaine

A
  • blocks both the initiation and conduction of nerve impulses by decreasing the neuronal membranes permeability to sodium ions
  • suppresses automaticity of conduction tissue
  • increases electrical stimulation threshold of ventricle and spontaneous depolarization of ventricles during diastole
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Don’t use Lidocaine in what instances?

A

Severe SA/AV and inter ventricular heart block

- corn allergy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Flecainide is indicated for what?

A

Ventricular arrhythmias (prevention)
paroxsysmal afib/flutter
PSVT

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What does flecainide do?

A
  • slows conduction in cardiac tissue by altering transport of ions across cell membranes
  • Causes slight prolongation of refractory periods
  • increases electrical stimulation threshold of ventricle
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What do you need to make sure you monitor in flecainide?

A

Renal/liver impariment

Dose adjust for eGFR

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

The beta blocker propranolol is in what classes of drugs

A

Non-selective beta blocker

Class 2 anti-arrhythmic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

The indications for propranolol include what?

A
  • angina
  • HTN
  • tachyarrhythmias
    essential tremor
    migraine px
    anxiety
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

You need to be be careful using propranolol in what patients?

A

DM

Asthma

18
Q

Why do you need to use caution in prescribing propranolol (and other b blockers) to Diabetics?

A

Because it can obscure early indications of hypoglycemia

19
Q

What can you use metoprolol for when it comes to arrhythmias?

A

a-fib

20
Q

What drug class is Metoprolol in?

A
  • B1 selective Beta blocker

- Class 2 anti-arrhythmics

21
Q

What is a benefit of using b blockers in heart failure

A

they decrease mortality

decrease mortality post-MI

22
Q

In metoprolol vs atenolol, what do you have to remember when it comes to patients with CKD?

A

That you have to adjust the dose for Atenolol. Metoprolol is better for patients with CKD

23
Q

Atenolol indications include what?

A
  • angina
  • HTN
  • stable, post MI
  • Supraventicular tachyarrythmias (dig toxicity)
24
Q

Amiodarone is in what drug class?

A

Class 3 - prolongation of action potential duration

25
Q

The indictations of amiodarone include what?

A
  • life threatening recurrent VF

- Unresponsive or unstable VT refractory to other anti-arrhythmics

26
Q

MOA of amiodarone

A

inhibits adrenergic stimulation affecting Na, K and Ca channels

  • prolongs action potential and refractory period in cardiac tissues
  • decrease AV conduction and sinus node function
27
Q

Calcium channel blockers (Varapamil) MOA is what?

A

Dilate coronary arteries

decrease myocardial oxygen demands

28
Q

Don’t use verapamil with what drugs?

A

B blockers

29
Q

Why don’t you use Verapamil in patients with CHF?

A

B/C of their action of decreasing myocardial contractility

30
Q

Adenosine is indicated for what?

A

PSVT

Pharm stress testing

31
Q

MOA of Adenosine in PSVT

A

slows conduction time through the av node, interrupting the reentry of pathways through he av node, restoring normal sinus rhythm

32
Q

the MOA of adenosine in stress testing is what?

A

causes coronary vasodilation and increases blood flow in normal coronary arteries with little to no increase in stenotic coronary arteries

33
Q

Do you use Adenosine for the treatment of fib, a flutter or Vtach?

A

Nope

34
Q

How do you administer adenosine?

A

IV

35
Q

What is the drug class of Digoxin?

A

Cardiac glycoside

36
Q

Explain the indications for digoxin?

A

Mild to moderate HF

Afib rate control

37
Q

MOA of Digoxin?

A

inhibits Na/K ATPase pump in myocardial cells, promoting influx Ca++ leading to increased contractility

  • also direct suppressor of AV noted which decreases ventricular rate
38
Q

what are the drug interactions with digoxin?

A

amiodarone
verapamil
multiple others

39
Q

MgSO4 is indicated for what?

A

Digitalis induced arrhythmias with low serum mag

low mg induced arrhythmias (VF, VT)

40
Q

What is a common S/E of MgSO4?

A

flushing

Pharm (12 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions