Dermatology meds Flashcards
1
Q
Bacitracin
topical antibiotic
A
- peptidoglycan
- superficial G+/mucosal infections
- highly nephrotoxic systemically
2
Q
Mupirocin
topical antibiotic
A
- Binds tRNA synthase
- Superficial G+ (including MRSA)
- Select G-
- mucosal infections
- Impetigo
3
Q
Polymixin B sulfate
topical antibiotic
A
- Superficial G- (Pseudomonas, E. coli, enterobacter, klebsiella)
- NO G+
- systemic toxicity
- NO in ESRD
4
Q
Nystatin
Oral/topical Antifungal
A
- binds sterols (increases membrane perm)
- Topical skin and mucosal candida ONLY
- SJS
5
Q
Ciclopirox Illumine
Topical Antifungal
A
- inhibits uptake of precursors, inhibiting membrane formation
- Dermatophytes, Candida, P. orbiculare
- Tinea versicolor, onychomycosis
6
Q
Fluconazole
Oral antifungal
A
- alters perm of cell wall
- Candida and dermatophyte fungal infections
- cryptococcal meningitis (AIDS)
- SJS
- Avoid in preg
- t1/2 = 30H
7
Q
Terbinafine
oral/topical antifungal
A
- inhibits sterol synth and disrupts wall
- oral: onychomycosis
- topical: tinea pedis
- Monitor ALT/AST and hepatic function
8
Q
Acyclovir
Nucleoside anti viral (oral/Topical)
A
Block herpes virus N.A. synthesis
- nephritis, seizures c OD
- decreases [MTX]
- accumulates only in virus infected cells
9
Q
Trentinoin
topical Acne med
A
- Binds RARs and RXrs to increase epidermal cell turnover
- Acne vulgaris
- makes acne worse initially
10
Q
Isotretinoin
oral acne med
A
- normalize keratinization of sebaceous gland and inhibit sebaceous gland size and function
- reduce P. Acne numbers
- oral tx of sever, cystic acne
- Lots of S/E: hepatotoxicity, abnormal menses, IBD, premature epiphyseal closure
11
Q
Adapaline
Retinoid-like anti-acne agent
A
- modulator of cell differentiation, keratinization and inflammation
- mild to moderate acne
- sun sensitization
- avoid in preg and lactation
12
Q
Benzyl Perozide
A
- antimicrobial action
- acne vulgaris
- start at low concentration to avoid drying
13
Q
Triamcinolone
topical steroid
A
- 0.025% and 0.5%
- Attaches to GR receptor and inhibits protein synthesis
- anti-inflammatory
- straie, easy brushing, fat distribution changes, HTN, skin atrophy
- Don’t use with NSAIDs or immunosuppressants
14
Q
Clobetasol Propionate
topical steroid
A
- Attaches to GR receptor, inhibiting protein synthesis
- anti-inflammatory
15
Q
Calcipotriene
Psoriasis drug, Topical
A
- Vit D topical
- Regulates skin cell production and proliferation
- moderately severe plaque psoriasis
- burning, hyperpig, skin atrophy
- Vit D toxicity
16
Q
Sulfasalazine
oral Psoriasis drug
A
- undefined local impact and systemic impact of decreased PG and other inflammatory cytokines
- Off label psoriasis, Crohns
- RA, ulcerative colitis
- varicella vaccine increase concentration
- HEMOLYTIC ANEMIA and photosensitivity
17
Q
Methotrexate
folate antimetabolite
A
- DHFR inhibitor –> apop of immune-inflammatory cells
- Psoriasis
- RA
- Can cause vasculitis, seizures, alopecia, Hepatic and pulm fibrosis
- folate inhibiting drugs
- don’t use in preg
18
Q
Hydroxyurea
Oral antimetabolite
A
- DNA synthesis interference
- Psoriasis (off-label)
- can cause edema, drowsiness, vasculitis, pulm fibrosis
- don’t use with live vaccines
- don’t use in preg
19
Q
Etanercept
BDMARD
A
- Blocks TNFalpha receptor inhibiting T-helper cell activity
- use for refractory psoriasis unresponsive to other tx
- can cause activation of serious infection, anemia, BM suppression, CHF exacerbation
- Don’t use with TB, HIV, Hep B or CHF
20
Q
Permethrin
Anti-parasitic
A
- Inhibits Sodium channel in parasite cell membrane disrupting nerve transmission causing paralysis and death
- Scabies - 5% cream
- Lice - 1% cream rinse
- Monitor skin irritation
- Preg cat b
