Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Pharm > Dermatology meds > Flashcards

Dermatology meds Flashcards

1
Q

Bacitracin

topical antibiotic

A
  • peptidoglycan
  • superficial G+/mucosal infections
  • highly nephrotoxic systemically
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Mupirocin

topical antibiotic

A
  • Binds tRNA synthase
  • Superficial G+ (including MRSA)
  • Select G-
  • mucosal infections
  • Impetigo
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Polymixin B sulfate

topical antibiotic

A
  • Superficial G- (Pseudomonas, E. coli, enterobacter, klebsiella)
  • NO G+
  • systemic toxicity
  • NO in ESRD
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Nystatin

Oral/topical Antifungal

A
  • binds sterols (increases membrane perm)
  • Topical skin and mucosal candida ONLY
  • SJS
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Ciclopirox Illumine

Topical Antifungal

A
  • inhibits uptake of precursors, inhibiting membrane formation
  • Dermatophytes, Candida, P. orbiculare
  • Tinea versicolor, onychomycosis
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Fluconazole

Oral antifungal

A
  • alters perm of cell wall
  • Candida and dermatophyte fungal infections
  • cryptococcal meningitis (AIDS)
  • SJS
  • Avoid in preg
  • t1/2 = 30H
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Terbinafine

oral/topical antifungal

A
  • inhibits sterol synth and disrupts wall
  • oral: onychomycosis
  • topical: tinea pedis
  • Monitor ALT/AST and hepatic function
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Acyclovir

Nucleoside anti viral (oral/Topical)

A

Block herpes virus N.A. synthesis

  • nephritis, seizures c OD
  • decreases [MTX]
  • accumulates only in virus infected cells
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Trentinoin

topical Acne med

A
  • Binds RARs and RXrs to increase epidermal cell turnover
  • Acne vulgaris
  • makes acne worse initially
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Isotretinoin

oral acne med

A
  • normalize keratinization of sebaceous gland and inhibit sebaceous gland size and function
  • reduce P. Acne numbers
  • oral tx of sever, cystic acne
  • Lots of S/E: hepatotoxicity, abnormal menses, IBD, premature epiphyseal closure
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Adapaline

Retinoid-like anti-acne agent

A
  • modulator of cell differentiation, keratinization and inflammation
  • mild to moderate acne
  • sun sensitization
  • avoid in preg and lactation
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Benzyl Perozide

A
  • antimicrobial action
  • acne vulgaris
  • start at low concentration to avoid drying
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Triamcinolone

topical steroid

A
  • 0.025% and 0.5%
  • Attaches to GR receptor and inhibits protein synthesis
  • anti-inflammatory
  • straie, easy brushing, fat distribution changes, HTN, skin atrophy
  • Don’t use with NSAIDs or immunosuppressants
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Clobetasol Propionate

topical steroid

A
  • Attaches to GR receptor, inhibiting protein synthesis

- anti-inflammatory

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Calcipotriene

Psoriasis drug, Topical

A
  • Vit D topical
  • Regulates skin cell production and proliferation
  • moderately severe plaque psoriasis
  • burning, hyperpig, skin atrophy
  • Vit D toxicity
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Sulfasalazine

oral Psoriasis drug

A
  • undefined local impact and systemic impact of decreased PG and other inflammatory cytokines
  • Off label psoriasis, Crohns
  • RA, ulcerative colitis
  • varicella vaccine increase concentration
  • HEMOLYTIC ANEMIA and photosensitivity
17
Q

Methotrexate

folate antimetabolite

A
  • DHFR inhibitor –> apop of immune-inflammatory cells
  • Psoriasis
  • RA
  • Can cause vasculitis, seizures, alopecia, Hepatic and pulm fibrosis
  • folate inhibiting drugs
  • don’t use in preg
18
Q

Hydroxyurea

Oral antimetabolite

A
  • DNA synthesis interference
  • Psoriasis (off-label)
  • can cause edema, drowsiness, vasculitis, pulm fibrosis
  • don’t use with live vaccines
  • don’t use in preg
19
Q

Etanercept

BDMARD

A
  • Blocks TNFalpha receptor inhibiting T-helper cell activity
  • use for refractory psoriasis unresponsive to other tx
  • can cause activation of serious infection, anemia, BM suppression, CHF exacerbation
  • Don’t use with TB, HIV, Hep B or CHF
20
Q

Permethrin

Anti-parasitic

A
  • Inhibits Sodium channel in parasite cell membrane disrupting nerve transmission causing paralysis and death
  • Scabies - 5% cream
  • Lice - 1% cream rinse
  • Monitor skin irritation
  • Preg cat b

Pharm (12 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions