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Pharm > Hem Onc Meds > Flashcards

Hem Onc Meds Flashcards

1
Q

What is the drug class of Iron?

A

Hematinics

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2
Q

What is the MOA of Iron?

A

Supplement

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3
Q

What are the indications of Iron?

A

Iron Deficiency

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4
Q

What are the common s/e of iron?

A 
n/v/d
constipation
abdominal cramps
black stools
anaphylaxis
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5
Q

Contraindications of iron

A

anaphylaxis
Hemochromatosis
Hemolytic anemia

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6
Q

What are the common drug interactions with Iron?

A

Antacids
Phenytoin
Quinolone and Tetracycline abx bind iron

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7
Q

Monitoring for Iron

A

Serrum ferritin
transferrin saturation
Hgb
reticulocytes

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8
Q

What is the drug class of Deferoxamine?

A

Iron Chelators

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9
Q

What is the MOA of Deferoxamine?

A

Chelates iron from hemosiderin, ferritin, transferrin (not from hgb or cytochromes)

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10
Q

What are the indications of Deferoxamine?

A

Excess serum iron levels

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11
Q

Cyanacobalamin

B12 Drug class

A

vitamin

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12
Q

What is the MOA of Cyanacobalamin

B12

A

Rate limiting cofactor in conversion folate to active form, and DNA synthesis

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13
Q

What is the Indication of Cyanacobalamin

B12?

A

B12 deficiency (megaloblastic anemia, peripheral neuropathy, depression, CVD)

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14
Q

Cyanacobalamin

B12 common S/E?

A

Painful by injection

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15
Q

What are common drug interactions of Cyanacobalamin

B12?

A

Long term acid suppression therapy metformin

phenytoin

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16
Q

What do you need to monitor for people taking Cyanacobalamin

B12?

A

[B12] serum
homocysteine
methylmalonic acid levels
replenishment regimens

17
Q

What is the replenishment regimen for Cyanacobalamin

B12?

A

IM 1000mcg QD for 1-2 weeks, then 1000mcg weekly, then 1000mcg monthly

18
Q

Folic acid drug class?

A

Nutritionals

19
Q

What is the MOA of Folic acid?

A

Cofactor in DNA synthesis

20
Q

What are the indications for Folic acid?

A

Folate deficiency from megaloblastic anemia
Neural tube defects during pregnancy
CVD

21
Q

What are common s/e of folic acid?

A

Bronchospasm
Flushing
Pruritis (rare)

22
Q

Contraindications of Folic Acid?

A

Hypersensitivity

23
Q

What are drugs that will interact with Folic Acid?

A 
Phenyobarbitol
Phenytoin
Primidone levels decreased by folic acid
trimethoprim
MTX depletes folic acid levels
24
Q

What NB-DMARD must you supplement with folic acid?

A

Methotrexate

25
Q

What do you need to monitor when taking folic acid?

A

Serum folic acid
RBC folate level
Variable dosing 1-5mg Daily

26
Q

What do you need to consider when treating patients with end stage renal disease?

A

Dialysis removes folic acid

27
Q

What is another disease that leads to the depletion of folic acid stores?

A

Alcoholism

28
Q

What is the drug class of Epoetin alfa?

A

Erythrocyte-stimulating agents

29
Q

What is the MOA of Epoetin alfa?

A

Stimulates erythroid proliferation and differentiation; induces release of reticulocytes

30
Q

What are the indications of epoetin alfa?

A

Low RBC secondary to ESRD, HIV, antineoplastic therapy

RA

31
Q

What is the drug class of Figrastim?

A

Myeloid Growth factors: G-CSF

32
Q

What is the moa of Filgrastim?

A
  1. Stimulates proliferation and differentiation of myeloid cells
  2. increased phagocytic capacity and prolongs survival of mature neutrophils
  3. Mobilizes peripheral neutrophils
33
Q

Indications of Filgrastim?

A

Neutropenia secondary to chemotherapy

Pharm (12 decks)

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