Hem Onc Meds

Question 1

What is the drug class of Iron?

Answer 1

Hematinics

Question 2

What is the MOA of Iron?

Answer 2

Supplement

Question 3

What are the indications of Iron?

Answer 3

Iron Deficiency

Question 4

What are the common s/e of iron?

Answer 4

n/v/d
constipation
abdominal cramps
black stools
anaphylaxis

Question 5

Contraindications of iron

Answer 5

anaphylaxis
Hemochromatosis
Hemolytic anemia

Question 6

What are the common drug interactions with Iron?

Answer 6

Antacids
Phenytoin
Quinolone and Tetracycline abx bind iron

Question 7

Monitoring for Iron

Answer 7

Serrum ferritin
transferrin saturation
Hgb
reticulocytes

Question 8

What is the drug class of Deferoxamine?

Answer 8

Iron Chelators

Question 9

What is the MOA of Deferoxamine?

Answer 9

Chelates iron from hemosiderin, ferritin, transferrin (not from hgb or cytochromes)

Question 10

What are the indications of Deferoxamine?

Answer 10

Excess serum iron levels

Question 11

Cyanacobalamin

B12 Drug class

Answer 11

vitamin

Question 12

What is the MOA of Cyanacobalamin

B12

Answer 12

Rate limiting cofactor in conversion folate to active form, and DNA synthesis

Question 13

What is the Indication of Cyanacobalamin

B12?

Answer 13

B12 deficiency (megaloblastic anemia, peripheral neuropathy, depression, CVD)

Question 14

Cyanacobalamin

B12 common S/E?

Answer 14

Painful by injection

Question 15

What are common drug interactions of Cyanacobalamin

B12?

Answer 15

Long term acid suppression therapy metformin

phenytoin

Question 16

What do you need to monitor for people taking Cyanacobalamin

B12?

Answer 16

[B12] serum
homocysteine
methylmalonic acid levels
replenishment regimens

Question 17

What is the replenishment regimen for Cyanacobalamin

B12?

Answer 17

IM 1000mcg QD for 1-2 weeks, then 1000mcg weekly, then 1000mcg monthly

Question 18

Folic acid drug class?

Answer 18

Nutritionals

Question 19

What is the MOA of Folic acid?

Answer 19

Cofactor in DNA synthesis

Question 20

What are the indications for Folic acid?

Answer 20

Folate deficiency from megaloblastic anemia
Neural tube defects during pregnancy
CVD

Question 21

What are common s/e of folic acid?

Answer 21

Bronchospasm
Flushing
Pruritis (rare)

Question 22

Contraindications of Folic Acid?

Answer 22

Hypersensitivity

Question 23

What are drugs that will interact with Folic Acid?

Answer 23

Phenyobarbitol
Phenytoin
Primidone levels decreased by folic acid
trimethoprim
MTX depletes folic acid levels

Question 24

What NB-DMARD must you supplement with folic acid?

Answer 24

Methotrexate

Question 25

What do you need to monitor when taking folic acid?

Answer 25

Serum folic acid
RBC folate level
Variable dosing 1-5mg Daily

Question 26

What do you need to consider when treating patients with end stage renal disease?

Answer 26

Dialysis removes folic acid

Question 27

What is another disease that leads to the depletion of folic acid stores?

Answer 27

Alcoholism

Question 28

What is the drug class of Epoetin alfa?

Answer 28

Erythrocyte-stimulating agents

Question 29

What is the MOA of Epoetin alfa?

Answer 29

Stimulates erythroid proliferation and differentiation; induces release of reticulocytes

Question 30

What are the indications of epoetin alfa?

Answer 30

Low RBC secondary to ESRD, HIV, antineoplastic therapy

RA

Question 31

What is the drug class of Figrastim?

Answer 31

Myeloid Growth factors: G-CSF

Question 32

What is the moa of Filgrastim?

Answer 32

1. Stimulates proliferation and differentiation of myeloid cells
2. increased phagocytic capacity and prolongs survival of mature neutrophils
3. Mobilizes peripheral neutrophils

Question 33

Indications of Filgrastim?

Answer 33

Neutropenia secondary to chemotherapy