Next 25 Flashcards
What is Amitriptyline’s brand name? MOA? Venlafaxine? MOA? Desvenlafaxine? MOA?
Amitriptyline’s dosing/strength?
Venlafaxine’s dosing/Strength?
Desvenlafaxine dosing/strength?
Keypoints/ CI’s for Amitriptyline? Venlafaxine and desvenlafaxine?
Elavil,Increases Serotonin and Norepinephrine. Effexor, selectively inhibits reuptake of Sero and Nore. Pristiq, same as Effexor.
25-50 mg qhs and gradually increase 100-300 mg. Oral tablet- 10-150 mg.
IR: 75- 225 mg in 2-3 divided doses. ER: same but qday. 37.5-225 mg tabs.
50 mg qday, 25-100 mg tab.
BBW is Suicidability, Can cause heart arrythmias, anticholinergic, tremor, sedation. CI’d in MAOI use or acute recovery phase following MI.
Same BBW, Watch for seizures, insomnia, hypderhydrosis, xerostemia. CI’d in MAOI use and usually used with linzeolid.
What is Allopurinol’s brand name? Colchicine brand name? MOA for Allopurinol? Colchicine?
Allopurinol(Aloprim) dosing/strength?
Colchicine(colcrys) dosing/strength?
Keypoints/CI’s for Allopurinol(Aloprim) and Colchicine(colcrys)?
Zyloprim, Aloprim. Colcrys, Inhibit Xanthine Oxidase. inhibits β-tubulin polymerization into microtubules,
preventing activation, degranulation, and migration of
neutrophils associated with mediating some gout symptoms
start at 100 mg/day and increase 100 mg per week until desired uric acid level. Max 800 mg/day. Oral tablet- 100,300 mg. Also IV.
1.2 mg initial flare then .6 mg later(no more than 1.8 per hour), prophylaxis .6 mg qday or BID no more than 1.2 per day. Cap and tab .6 mg
Diarrhea, skin rash, keep taking even if you aren’t experiencing a gout flare. CI’d in hypersensitivity. Concomittant of cyp 2 something for hepatoxicity in colcichine.
What is Amlodipine’s brand name? Amlodipine and Benazepril? Dilitiazem? Nifedipine?
What are their MOA’s?
Key points/CI’s for the CCB’s?
Norvasc, Lotrel,Cardizem(or cartia, taztia, tiazac), Adalat( or Afeditab, Procardia).
Acts on vascular smooth muscle to produce peripheral
arterial vasodilation by inhibiting calcium ions from entering select voltage-sensitive areas of vascular smooth muscle. Dilitiazem is a NON dihydropyridine.
BBW for fetal Toxicity in Amlodipine and Benazepril(lotrel).Watch for Peripheral edema, flushing, hypotension, lightheadedness, gingival hyperplasia. bradycardia(dilitiazem), CI’d in Hypersensitive patients,Sick sinus syndrome(or hypotension, 2nd or 3rd degree AV block, acute MI for Dilitiazem), history of angioedema or concurrent use of allskiren(Lotrel), use in patients with STEMI(nifedipine( Adalat).
Dosing/strengths for Amlodipine( Norvasc)?
Dosing/strengths for Dilitiazem( Cardizem)?
Dosing/strenghts for Nifedipine(Procardia)?
5-10 mg qday, 2.5-10 mg tab, also suspension.
120-320 mg daily, Max 480 mg.day. 30-420 mg pills.
IR(angina only): 10-20 TID, Max 180. ER: HTN and Angina:30-90 qday, max 120. Comes in 10-90 mg tabs.
What is Benazepril’s brand name? Enalapril? Lisinopril? Hydochlorthiazide? Lisinopril and HCTZ?
What are their MOA’s?
Key points. CI’s for the ACE inhibitors? HCTZ?
Lotensin, Vasotec, Prinivil or Zestril. Microzide. Zestoretic.
Inhibits Antgiotensin 1-2.Inhibits sodium reabsorption in the distal tubules causing
increased excretion of sodium and water as well as
potassium and hydrogen ions
BBW is fetal toxicity, May cause dry cough, check K+ and sCr, Angioedema, lightheadedness,dizziness, hypotension. CI’d in patients who got angioedema, concurrent use of alliskiren in diabetic patients.
Watch for Hypokalemia, photosensitivity, sulfacross allergy. CI’d in hypersensitivity and Anuria.
Dosing/Strength’s of Benazepril(Lotensin)?
Dosing/Strength’s of Enalapril(Vasotec)?
Dosing/Strength’s of Lisinopril(Prinivil)?
Dosing/Strength’s of Hydrochlorothiazide(Microzide)?
20-80 mg as one dose or 2 evenly divided doses. 5-40 mg tab.
5-40 mg daily as one or 2 evenly divided doses. Doses over 20 should be bid. 2.5-20 mg tab.
5-40 mg daily,2.5-40 mg tab.
12.5-50 mg qday,12.50-50 mg tab.
What is Irbesartan’s brand name? Irbesartan and HCTZ? Losartan? Losartan and HCTZ? Olmesartan? Olmesartan and HCTZ? Valsartan and HCTZ?
MOA for the Sartan’s?
Key points. CI’d for sartan’s?
Avapro, Avalide,Cozaar, Hyzaar, Benicar, Benicar HCT, Diovan HCT.
Antagonizes angiotensin receptors,
All the same as the ACE inhibitors.
Dosing/Strength’s for Irbesartan(Avapro)?
Dosing/Strength’s for Losartan(Cozaar)?
Dosing/Strength’s for Olmesartan(Benicar)?
Dosing/Strength’s for Valsartan/HCTZ(Diovan HCT)?
150-300 mg qday, 75-300 mg tabs.
50-100 mg qday, 25-100 mg tabs.
20-40 mg qday,5-40 mg tabs.
160/12.5-320/25 mg qday.
What is Atorvastatin’s brand name? Pravastatin? Rosuvastatin? Simvastatin? Simvastatin and HCTZ?
Statin’s MOA?
Key points/ CI’d for Statins?
Lipitor, Pravachol, Crestor, Zocor, Vytorin.
Inhibits 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase.
Watch for muscle pain and weakness and diarhhea, CI’d in Active Liver Disease, Pregnancy, Breastfeeding, unexplained high transamines. Simvastatin can’t used CYP3A4 inhibitors.
Dosing/Strength’s of Atorvastatin(Lipitor)?
Dosing/Strength’s of Pravastatin(Pravachol)?
Dosing/Strength’s of Rosuvastatin(Crestor)?
Dosing/Strength’s of Simvastatin(Zocor)?
10-80 mg qday, tabs-10-80 mg.
40-80 mg qday, tabs 10-80 mg.
10-20 mg qday, may titrate to 40 mg. tabs-5-40 mg.
5-40 mg qdays, 5-80 mg tabs and suspension.
What is Atenolol’s brand name? Bisoprolol? Carvedilol? Metoprolol(succinate is long? Propanolol? Timolol?
What are their MOA’s?
Key points/CI’s for the Beta Blockers?
Tenormin, Zebeta, Coreg, Lopressor or Toprol, Inderal, Betimol or Timoptic.
Selectively blocks beta-1 receptors. Carvedilol, Timolol,, Propanolol are non selective. Timolol also lowers aqueous humor production and possibly increases outflow.
BBW Cessation of therapy(atenolol), Ischemic heart disease(metoprolol). Watch for Fatigue and lethargy, bradycardia, impotence, depression and vivid dreams, hypotension, Burning and stinging of eyes for timolol. CI’d in sinus bradycardia, greater than 1st degree heartblock, cardiogenic shock, overt cardiac failure, severe hepatic impairment, asthma.
Dosing/Strength’s for Atenolol(Tenormin)?
Dosing/Strength’s for Bisoprolol(Zebeta)?
Dosing/Strength’s for Carvedilol(Coreg)?
Dosing/Strength’s for Metoprolol(Lopressor)?
Dosing/Strength’s for Propanolol(Inderal)?
Dosing/Strength’s for Timolol?
25-50 mg once daily, can go up to 100, BID okay. Tabs 25-100 mg, solution and recons as well.
5-10 mg qday, max 20. tab 5-10 mg.
HTN: 6.25-25 mg BID(max 25 mg BID). Hf: 25 mg BID(max 50 mg). 3.125-80 mg tab.
25-400 mg qday. except HTN is BID. 25-200 mg tablet. Comes IV as well(tartrate).
80-240 mg in 2-3 divided doses or ER is 80-160 mg once daily. Tab is 10-80 mg. Comes IV and solution as well.
Gel one drop once daily, solution one drop BID unless controlled than can do once daily. .25% and .5% solution. Solution gel and tablet.
