First 25 Flashcards
What is Paroxetine’s brand name? What does it treat and drug class?
Paroxetine dosing? When is it CI’d? What is it’s blackbox warning and anything else to know?
Paxil, Pexeva. MDD,OCD, GAD, PTSD, etc. SSRI,
25-65 mg once a day.(Max 75 mg once daily). MAOI use within 14 days, Use with linzeolid and pregnancy. Suicidability and major anti depressant notes. Causes drowsiness, dry mouth, decreased libido, QTC prolongation.
What are Quetiapine and aripiprazole’s MOA and drug class?
Quietiapine and then aripiprazole’s brand name? What does it treat?
Quetiapine dosing? Abilify dosing?
Antagonist of Dopamine and Serotonin receptors. Second generation Atypical anti psychotics.
Seroquel, Abilify. Schizophrenia, MDD, Bipolar disorder.
300 mg to 800 mg QD, Depression 2-5 mg once daily, then it increases for schizophrenia and bipolar.
What class are the benzo’s?
What are the 5 benzo’s brand names?
What are the 5 benzo’s mechanism of action?
4
Alprazolam(Xanax),Clonazepam(Klonopin), Diazepam(Valium,Diastat),Lorazepam(Ativan), Temazepam(restoril).
Enhances the inhibitory effect of GABA on neuronal
excitability results by increased neuronal membrane
permeability to chloride ions
What are the main indications of the benzo’s? Which is the only one used for insomnia?
Main warnings with/ things to know for benzo’s?
What are the 2 benzos made available injection? What are the 3 anticonvulsants as well? which is the only capsule?
Anxiety, seizures, Panic, status ellipticus. Temazepam(restoril).
risk from concurrent use with opiods, drowsiness and sedation, avoid concurrent alcohol use. C/I’d in acute narrow angle glaucoma and liver disease.
Lorazepam(IV as well), Diazepam(rectal as well). LCD. Temazepam.
Dosing/ strengths for Alprazolam(xanax)?
Dosing/Strengths for Clonazepam(Klonopin)?
Dosing/Strengths for Diazepam(Valium/Diastat)?
Dosing/Strengths for Lorazepam(Ativan)?
Dosing/Strengths for Temazepam(restoril)?
0,25mg-1mg TID(4-6 mg per day). 0.25-3 mg tab strength.
0.5-2mg BID(max 4 mg) for panic.2-8mg in 2 divided doses for seizure(Max 20mg). 0.25-2mg tab strength.
2-10 mg BID to QID prn. 2,5,10 mg tab.
Anxiety: 2-6 mg in 2-3 divided doses. 0.5-2 mg tab.
15-30 mg qhs, 7.5-30 mg capsule.
What are the analgesic opiod brand names?
What are the classes of the opiod’s?
MOA?
Different indications other than pain?
Acetaminophen and codeine(tylenol with codeine), Buprenorphine(Buprenex, Butrans), Buprenorphine and Naloxone(Suboxone, Zubsolv), Fentanyl(Actiq, Duragesic, sublimaze, Fentora), Hydrocodone and Acetaminophen(Lorcet, Lortab, Vicodin, Xodol).
Fentanyl(duragesic) and Vicodin(hydro/APAP) are class 2. Rest are class 3.
Bind to opiod receptors in the CNS. Fentanyl- binds at sterospecific sites at many CNS receptors, increases pain receptors.
Buprenorphine and Naloxone(opiod dependance), general anesthetic, antidoperidine receptor(fentanyl).
Dosing/strength for Tylenol with Codeine?
Dosing/Strength for Buprenorphine(Butrans)?
Dosing/strength for Buprenorphine and Naloxone(suboxone,zubsolv)?
Dosing/strength Fentanyl( Actiq)?
Dosing/ Strength Hydro/APAP(Vicodin, Lortab)?
300/30mg q4h(max 4000/360 mg per day), 120/12mg(solution), Tab 300/30 or 60 mg.
Oral SLT:12-16 mg once daily, Buccal film 150 mcg q12h. Buccal film 75- 900 mcg, SLT-2 or 8 mg.
SL(tab and film): 16mg/4mg once daily, Buccal film 8.4/1.4 mg once daily.
Patch 12mcg-100 mcg/hr. Individualized to patient.
2.5 mg-10 mg q4-6h.(Max 4000 APAP 600 Hydro).
What are the patch opiods? Elixir/solution?
Important keys, CI’s for Tylenol with Codeine?
Important Keys, CI’s for buprenorphine and Hydrocodone/APAP?
Fentanyl(Duragesic, Actiq), Buprenorphine(Butrans). Hydro/APAP(Lortab), APAP/Codeine.
Medication errors,abuse, Hepatoxicity, Drugs affecting cytochrome p450, risk of use with benzos. Watch for Drowsiness, constipation, pruitis, avoid alcohol and other APAP products. GI obstruction, MAOI’s, Pain management in tonsilectamies, respiratory depression.
Watch for headache, sedation, REMS drugs, addiction abuse and misuse, respiratory depression, use with benzos, neonatal opiod withdrawal. risk with insertion and removal. CI’d in GI obstruction, Acute or Severe asthma, Respiratory depression.
Important Keys, CI’s for Suboxone?
Important keys, CI’s for fentanyl(duragesic, Actiq)?
Watch for headache, withdrawals, pain, diaphoresis. CI’d in hypersensitive patients.
Change patch every 72 hours, do not cut patch, watch for dizziness drowsiness and constipation, avoid alcohol. REMS program, abuse, Cytochrome p450 interacion, CI’d in hypersensitive patients, GI obstruction, respiratory depression.
What are Etancercept and Adalimumab’s brand names?
What is Etanercept(enbrel) and Adalimumab(Humira) MOA and what do they treat?
Dosing/strength for etancercept(enbrel).
Dosing/Strength for adalimumab(humira).
Enbrel, Humira
Binds to TNF-Alpha inhibiting subsequent cytokine stuff. Treats arthritis(humira treats chrons disease and psoriasis and ulcerative colitis too).
50mg subq qweek, Subq injection(50mg/ml) prefilled syringe(25mg/mL). Also comes solution recons.
40 mg subq every other week. subq injector comes 40mg, Subq pre filled syringe 10mg/.2-40mg/.8 ml.
Keypoints and CI’s for Etanercept(enbrel) and Adalmumuab(humira)-
What is Citalopram’s brand name? Escitalopram? Fluoxetine? Sertraline?
What are the SSRI’s MOA?
BBW is serious infections and malignancies,. Do not start or take if patient is sick,Hep B and tuberculosis screening should be done before starting,injection site reaction common,drug takes some time to work. Etanercept(enbrel) CI’d in Sepsis.
Celexa, Lexapro, Prozac or Sarafem, Zoloft.
Inhibit serotonin reuptake in the presynaptic neuron.
Dosing/ strengths for citalopram(celexa)?
Dosing/strength for escitalopram(lexapro)?
Dosing/strength for fluoxetine(Prozac,Sarafem)?
Dosing/strength for Sertraline(Zoloft)?
20-40 qday, max 20 mg in patients older than 60. Oral tablet- 10,20,40 mg(also comes in solution).
10mg-20mg qday, 5,10,20 mg tab(also comes in solution).
20-80mg qday,10-60 mg tab and capsule,comes in capsule, solution, tablet.
50mg-200 mg qday,25-100 mg tablet(also comes in concentrate).
Key points/CI’s for the SSRI’s?
What is Atomoxetine’s brand name? Amphetamine and Dextroamphetamine’s brand name? Dexmethylphenidate’s? Lisdexamefetamine Dimesylate?
What class are the drugs that treat ADHD?
What is Atomoxetines MOA? What about the amphetamines?
Watch for Suicidality, decreased libido, QTC prolongation, Drowsiness and insomnia, drymouth. CI’d in MAOI use in 2 weeks, concomittant with linezolid(not sertraline). Fluoxetine also has long half life and can cause anxiety.
Straterra, Adderrall, Focalin, Vyvanse
Class 2 except for Atomoxetine(straterra) is legend.
Selectively inhibits the reuptake of NE. Promote release of dopamine and norepinephrine
Drug Dosing/ strength for Atomoxetine(straterra)?
Drug dosing/strength for Dexmethylphenidate(Focalin)?
Drug dosing/strength for Dextroamphetamine(Adderrall)?
Drug dosing/strength for Lisdexamfetamine Dimesylate(Vyvanse)?
40-80mg in a single dose or 2 divided doses(max 100 mg/day). 10-100 mg tablet(tablet and suspension as well.)
2.5-5 mg BID(max 20), ER is 10-40 mg qday(max 40).2.5-40 mg capsule and tablet.
5-40 mg in 3 divided doses, ER 20-60 mg daily. 2.5-30 mg tablet and capsule, also solution.
30-70 mg daily max 70 mg daily. Capsule 40-70 mg(also tablet and chewable tablet).
Key points/ CI’s for Atomoxetine(straterra)?`
Key points/ CI’s for Dexmethylphenidate(Focalin)?
Key points/CI’s for Amphetamine(adderrall)?
Key points/ CI’s for Lisdexamfetamine(Vyvanse)?
BBW is suicidal ideation, Watch for headache, insomnia, decreased appetite and dry mouth. CI’d in MAOI use within 14 days, narrow angle glaucoma, cardiovascular disease, pheorchromocytoma.
BBW is dependance, watch for headache, insomnia, decreased appetite. CI’d in marked insomnia, glaucoma, MAOI use.
BBW is abuse potential and cardiovascular events, watch for hypertension, tachycardia, weight loss, insomnia. CI’d in Heart problems, glaucoma, MAOI use.
BBW is abuse and dependance, Watch for insomnia, dry mouth, decreased appetite, increased BP. CI’d for MAOI use.
