New Treatments for Schizophrenia

Question 1

What are some common reasons for non-response to standard treatments in Schizophrenia?

Answer 1

• Diagnosis incorrect
• Substance use
• Insufficient dose
• Insufficient duration
• Unusual genetic metabolism
• Drug interactions
• Insufficient adherence

Question 2

Stepped care for treatment resistant schizophrenia?

Answer 2

1) Two failed antipsychotics
2) Clozapine trial
3) Judicious use of add-on treatments

Question 3

What addition may be useful in the negative symptoms of schizophrenia?

Answer 3

Cariprazine

Question 4

What is some of the evidence for Amisulpride?

Answer 4

Excellent efficacy for positive symptoms after Clozapine, low EPS and weight gain risk due to Pure high affinity D2/3 antagonism.

Not yet available in US