Managing Side Effects of Antipsychotics Flashcards
What are some of the main side effects of antipsychotics?
Akathisia Weight gain QT prolongation Prolactin elevation Sedation
What receptors are responsible for the following side effects:
- Hypotension
- Dystonia
- Akathisia
- Hyperprolactinemia
- Sedation
- Weight gain
- Anticholinergic (dry mouth, constipation, blurred vision, cognitive)
- Hypotension: Alpha-1
- Dystonia, Akathisia, Prolactin: Dopamine-2
- Sedation and weight gain: Histamine-1
- Anticholinergic: Muscarinic 1-5
What is Neuroleptic Malignant Syndrome? When is the onset?
Tetras of Fever, Rigidity, mental status change and autonomic instability (tachycardia, diaphoresis)
Onset usually within 2 weeks of starting antipsychotic
What are some things to consider prescribing with Clozapine when initiated?
Stool softeners due to constipation risk
What are three general antipsychotic-induced motor side effects to look for?
Akathisia
Parkonsinism
Traduce Dyskinesia
What are some possible treatments for Akathisia?
- Reduce dose or switch
- Propranolol
- Mirtazapine
How often should AIMS be completed?
At least annually
Management of TD?
- Slowly taper
- Switch to Seroquel or Clozapine if possible
- VMAT inhibitors for symptoms
Management of Parkonsinism?
Lower dose, switch, anticholinergic
What is something you can add to reduce prolactin levels?
Abilify
