New Pharmacology Flashcards
A neurotransmitter which is synthesised by a vesicular enzyme
Insulin
Stages of ADME affected in a patient who is malnourished
adsorption and distribution
Bioavailability refers to the amount of drug that reaches the _____?
Systemic circulation
Drug transport across the GI tract is not affected by _____?
Phase 2 metabolism
If metabolism of a drug decreases, half-life _____?
Increases
What happens in a first order kinetics?
Rate of elimination is directly proportional to drug concentration
In regard to steady state, how many half-lives are needed to occur to reach the point at which drug accumulation and elimination are balanced?
4-5
In drug metabolism, which enzyme is responsible for phase 1 oxidation reactions?
Cytochrome P450
Local anaesthetics are _____?
Weak bases
Phase 2 drug metabolism usually forms _____?
Inactive metabolites
What is it when lipid-soluble, uncharged drugs diffuse back into the systemic circulation?
Passive reabsorption
What requires active transport systems with low specificity?
Proximal tubular secretion
When is the rate of elimination constant regardless of concentration?
Zero order elimination
Which enzyme inducer increases paracetamol activity?
Ethanol
Which receptor types are not found on the plasma membrane of the cell?
Glucocorticoid receptors
