Neurotransmitters and Receptors - Linger

Question 1

excitatory

Answer 1

glutamate

aspartate

Question 2

inhibitors

Answer 2

GABA

glycine

Question 3

drugs

Answer 3

not specific - they are selective

Question 4

define NTs

Answer 4

localized to presynaptic terminal
released from presynaptic - Ca manner
exogenous application should mimic NT action

Question 5

endocannaboids

Answer 5

retrograde messenger

Question 6

monoamine transporter

Answer 6

NE signaling

NET reuptake from cleft

Question 7

cocaine

Answer 7

block NE reuptake

Question 8

amphetamine

Answer 8

compete with NE at NET and VMAT

Question 9

inotropic receptor

Answer 9

ligand gated ion channel

Question 10

activate inotropic receptors

Answer 10

glutamate
GABA
ACh
glycine
serotonin

Question 11

metabotropic receptors

Answer 11

GPCR

slow transmission

majority of NT signaling

Question 12

glutamate receptors

Answer 12

non-NMDA and NMDA

Question 13

NMDA receptor

Answer 13

inotropic
-for glutamate

ligand gated Na/K channel highly permeable to Ca

blocked by Magnesium - until depolarized

only allow entry of Ca if depolarized
-coincidence detector

Question 14

phencyclidine

Answer 14

noncompetitive antagonist at NMDA receptor

Question 15

ketamine

Answer 15

noncompetitive antagonist at NMDA receptor

Question 16

migraine

Answer 16

excess glutamate release

Question 17

excitotoxicity

Answer 17

mediated by glutamate

Question 18

alzheimers tx

Answer 18

memantine - NMDA receptor antagonist

moderate to severe dementia

to stop glutamate excitotoxicity

Question 19

GABA-A receptors

Answer 19

binding site for benzos and barbituates

Question 20

alprazolam

Answer 20

benzo

Question 21

diazemap

Answer 21

benzo

Question 22

tx of GAD, panic disorder

Answer 22

benzos

Question 23

phenobarbital

Answer 23

barbituate

Question 24

tx of epilepsy

Answer 24

barbituates

Question 25

co-agonist with glutamate at NMDA receptors

Answer 25

glycine

Question 26

M1

Answer 26

excitation

Question 27

M2

Answer 27

inhibit

Question 28

muscarine

Answer 28

muscarinic agonist

Question 29

pilocarpine

Answer 29

muscarinic agonist

Question 30

atropine

Answer 30

muscarinic antagonist

Question 31

alzheimers disease

Answer 31

reduced cerebral production of choline acetyl transverase decreased ACh synthesis tx - AChE inhibitors

Question 32

precursor to dopamine

Answer 32

tyrosine

Question 33

D1

Answer 33

stimulators

Question 34

D2

Answer 34

inhibitors

Question 35

increased dopamine release

Answer 35

amphetamines

Question 36

dopamine uptake blocker

Answer 36

cocaine

Question 37

synthesis of NE

Answer 37

from dopamine

Question 38

mood disorders/depression

Answer 38

NE

Question 39

synthesis of serotonin

Answer 39

from tryptophan

Question 40

depression

Answer 40

decreased 5-HT function tx - fluoxetine - prozac SSRI

Question 41

SSRI

Answer 41

fluoxetine

Question 42

ondansetron

Answer 42

anti-emetic - serotonin receptor antagonist

Question 43

H1

Answer 43

excitation

Question 44

H2

Answer 44

excitation

Question 45

neuropeptides

Answer 45

synthesized in cell body

Question 46

NT

Answer 46

synthesized in nerve endings

Question 47

transmitter of pain

Answer 47

substance P

Question 48

mu receptor

Answer 48

high affinity for endorphins pain relief - opiods