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Neuro II Exam 1 > Neurotransmitters and Receptors - Linger > Flashcards

Neurotransmitters and Receptors - Linger Flashcards

1
Q

excitatory

A

glutamate

aspartate

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2
Q

inhibitors

A

GABA

glycine

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3
Q

drugs

A

not specific - they are selective

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4
Q

define NTs

A

localized to presynaptic terminal
released from presynaptic - Ca manner
exogenous application should mimic NT action

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5
Q

endocannaboids

A

retrograde messenger

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6
Q

monoamine transporter

A

NE signaling

NET reuptake from cleft

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7
Q

cocaine

A

block NE reuptake

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8
Q

amphetamine

A

compete with NE at NET and VMAT

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9
Q

inotropic receptor

A

ligand gated ion channel

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10
Q

activate inotropic receptors

A 
glutamate
GABA
ACh
glycine
serotonin
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11
Q

metabotropic receptors

A

GPCR

slow transmission

majority of NT signaling

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12
Q

glutamate receptors

A

non-NMDA and NMDA

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13
Q

NMDA receptor

A

inotropic
-for glutamate

ligand gated Na/K channel highly permeable to Ca

blocked by Magnesium - until depolarized

only allow entry of Ca if depolarized
-coincidence detector

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14
Q

phencyclidine

A

noncompetitive antagonist at NMDA receptor

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15
Q

ketamine

A

noncompetitive antagonist at NMDA receptor

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16
Q

migraine

A

excess glutamate release

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17
Q

excitotoxicity

A

mediated by glutamate

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18
Q

alzheimers tx

A

memantine - NMDA receptor antagonist

moderate to severe dementia

to stop glutamate excitotoxicity

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19
Q

GABA-A receptors

A

binding site for benzos and barbituates

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20
Q

alprazolam

A

benzo

21
Q

diazemap

A

benzo

22
Q

tx of GAD, panic disorder

A

benzos

23
Q

phenobarbital

A

barbituate

24
Q

tx of epilepsy

A

barbituates

25
Q

co-agonist with glutamate at NMDA receptors

A

glycine

26
Q

M1

A

excitation

27
Q

M2

A

inhibit

28
Q

muscarine

A

muscarinic agonist

29
Q

pilocarpine

A

muscarinic agonist

30
Q

atropine

A

muscarinic antagonist

31
Q

alzheimers disease

A

reduced cerebral production of choline acetyl transverase

decreased ACh synthesis

tx - AChE inhibitors

32
Q

precursor to dopamine

A

tyrosine

33
Q

D1

A

stimulators

34
Q

D2

A

inhibitors

35
Q

increased dopamine release

A

amphetamines

36
Q

dopamine uptake blocker

A

cocaine

37
Q

synthesis of NE

A

from dopamine

38
Q

mood disorders/depression

A

NE

39
Q

synthesis of serotonin

A

from tryptophan

40
Q

depression

A

decreased 5-HT function

tx - fluoxetine - prozac

SSRI

41
Q

SSRI

A

fluoxetine

42
Q

ondansetron

A

anti-emetic - serotonin receptor antagonist

43
Q

H1

A

excitation

44
Q

H2

A

excitation

45
Q

neuropeptides

A

synthesized in cell body

46
Q

NT

A

synthesized in nerve endings

47
Q

transmitter of pain

A

substance P

48
Q

mu receptor

A

high affinity for endorphins

pain relief - opiods

Neuro II Exam 1 (14 decks)

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