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Prite- Neurology > Neurotransmitters > Flashcards

Neurotransmitters Flashcards

1
Q

DA release in what structure represents common final event assoc w reinforcing effects of
opiates, cocaine, amphetamines, nicotine, PCP, and alcohol? (4x)

A

NUCLEUS ACCUMBENS

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2
Q

Role of glycine at NMDA receptor (x2)

A

OBLIGATE COAGONIST

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3
Q

Which neurotransmitter system is the last to mature in the CNS of children and
adolescents? (2x)

A

CHOLINERGIC

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4
Q

A compound that increases muscle mass by increasing episodic secretion of GH (2x):

A

GAMMA HYDROXYLBUTYRATE

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5
Q

Highest concentration of 5HT producing cells in brain?

A

raphe nuclei

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6
Q

DA and what else regulates reward circuitry

A

gaba

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7
Q

Neuroimaging technology most useful in studying connectivity pathways:

A

SINGLE PHOTON EMISSION CT SCAN

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8
Q

What area of the body has the most serotonin?

A

GI TRACT

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9
Q

What neurotransmitter has been associated with anxiety?

A

norepi

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10
Q

Positive allosteric modulators of neurotransmitter-gated, multimeric ion channels do what?

A

INCREASE PROBABILITY OF OPENING IN

PRESENCE OF A LIGAND

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11
Q

Where are the major clusters of cell bodies containing serotonin in brain?

A

RAPHE NUCLEUS IN THE BRAIN STEM

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12
Q

Principal mechanism of termination of synaptic activity of dopamine in prefrontal cortex?

A

diffusion

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13
Q

Opiates inhibit Camp dependent protein phosphorylation in:

A

LOCUS CERULEUS

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14
Q

Neurotransmitter maintains consistent levels with age:

A

sero

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15
Q

Which neurotransmitters are reduced in quantity, uptake and turnover is spasticity?

A

gylcine and gaba

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16
Q

The cognitive enhancement associated with experimental D-cycloserine treatment in pt’s
with schizophrenia has been attributed to enhancement of NMDA receptor activity by which
of the following neurotransmitters?

A

glycine

17
Q

In addiction, dopaminergic neurons project to nucleus accumbens. Cell bodies of these
neurons reside in which area of brain?

A

VTA

18
Q

Which neurotransmitter is predominantly inhibitory?

A

glycine

19
Q

Neurotransmitter assoc w/ reward & reinforcement in nicotine dependence

A

dopa

20
Q

Prostaglandin D2 increases extracellular levels of…

A

adenosine

21
Q

Which is a retrograde neurotransmitter?

A

ENDOCANNABINOIDS

22
Q

Characteristics of Ach receptors in cerebral cortex

A

BOTH INHIBITORY AND EXCITATORY

23
Q

Neurohormone for social bonding

A

oxytocin

24
Q

Neurotransmitter from responsible for rewarding

nature of drug abuse

A

dopa

25
Q

Low CSF levels of this neurotransmitter metabolites is associated with suicidality?

A

5-HIAA

26
Q

What is the 5HT3 receptor classification?

A

ligand-gated

27
Q

Pain by neurogenic inflammation mediated by?

A

sUBSTANCE P

28
Q

Decreased level of what NT is most associated with
depressed mood, poor sleep, and poor impulse
control

A

sero

29
Q

Psych stress increases cortisol and prolonged cortisol is associated with bad outcomes. Stress
also affects other hormones. Increase in which hormone is correlated with decreased PTSD
severity most likely due to hormone’s anti-glucocorticoid properties:

A

dhea

30
Q

Activation of this receptor is likely responsible for anti-anxiety, motor-impairment, and
sedative hypnotic effects of alcoho

A

gaba-a

31
Q

Neurotransmitter regulating sleep and wakefulness?

A

histamine

32
Q

What neurotransmitter is thought to play a key role in fine-tuning working memory function
in the dorsolateral prefrontal cortex?

A

dopa

33
Q

Which of the following levels would be affected what changes in tyrosine hydroxylase levels:
Dopaminergic, Gutaminergic, GABAminergic, Serotonergic, Histaminergic,

A

dopa

34
Q

Blockade of which receptor causes sedation and weight gain side effects for antipsychotics
and antidepressants?

A

histamine

35
Q

What neurotransmitter present in the periaqueductal gray matter is involved in the
mediation of pain?

A

endorphins

36
Q

Which neurotransmitter, IF dysfunctional, most replicates core symptoms of schizophrenia?

A

glutamate

Prite- Neurology (14 decks)

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