muscle/nerve Flashcards
Myasthenia gravis associated w/ which EMG finding? (10x)
DECREASED AMPLITUDE WITH REPETITIVE MOTOR NERVE STIMULATION
36 y/o pt w pain behind L ear progressing to numbness of L side of face, tearing of L eye, discomfort w low frequency sounds, left facial weakness on exam. Dx? (9x)
IDIOPATHIC BELL’S PALSY
Treatment of Trigeminal Neuralgia: (7x)
GABAPENTIN (BUT MOST EFFECTIVE IS CARBAMAZEPINE)
37 y/o truck driver w numbness of L hand, inc severity in past 2 yrs. Reduced pinprick sensation on L little/ring fingers, atrophy of hypothenar muscle. (6x)
ULNAR NERVE LESION
22 y/o with pain in the right hand that radiates into the forearm and bicep muscle. Paresthesias in the palm of the hand, thumb, index, middle ring finger. Sensory systems in the ring finger split the ringer finger longitudinally. Dx? (6x)
MEDIAN NERVE ENTRAPMENT AT THE WRIST
Positive sharp waves on EMG. (5x)
AMYOTROPHIC LATERAL SCLEROSIS
Stiffness of legs while walking and spasms of LE while sleeping. Stiff legged gait, adducts legs while walking. Increased LE tone/spastic catch, hyperactive knee jerks, ankle jerk clonus. Increased Romberg sway. (5x)
CERVICAL SPONDYLOSIS
Persistent numbness in the L hand, decreased sensation in 4th/5th digits (palmar/dorsal), weak finger abduction/adduction especially 5th digit: (4x)
ULNAR NERVE ENTRAPMENT AT THE ELBOW
Right neck pain, tends to rotate neck to left - touching the chin prevents deviation - prominent right SCM spasm. Tx? (4x)
BOTULINUM TOXIN
Progressive weakness over several days - absent reflexes worse in lower extremities - slow conduction velocity, conduction block A 54-year-old patient had a viral upper respiratory infection 2 weeks ago and now presents with a 3-day episode of progressive, symmetric weakness in the legs, and tingling in the toes and fingers. On exam, Achilles and patellar deep tendon reflexes are diminished. Nerve conduction studies demonstrate decreased conduction velocity and decreased amplitude of action potentials. The most likely Dx: (4x)
ACUTE INFLAMMATORY DEMYELINATING POLYNEUROPATHY
14 y/o pt after a demanding physical test becomes extremely weak and unable to stand. PE is positive for depressed DTR’s. Labs: K=2.8. Hx of similar episodes after strenuous exercises. EKG: minimally prolonged PR, QRS, QT interval. Father and grandfather had similar episodes. Dx? (3x)
PERIODIC PARALYSIS
26 y/o pt w/ sudden onset back pain. Spasms in R paraspinal muscles in the lumbar region. Straight leg raising on the R is limited by sharp pain at 45 degrees. Ankle jerk on L is diminished. No muscle weakness, no sensory deficit. Next step? (3x)
ORDER MRI SCAN OF THE LUMBAR SPINE
Myasthenia gravis can be diagnosed in 80-90% of cases by identification of serum antibodies against what? (3x)
ACETYLCHOLINE RECEPTORS
Mechanism of action of botulinum toxin at neuromuscular junction: (3x)
INHIBITION OF ACETYLCHOLINE FROM PRESYNAPTIC TERMINALS
During 2nd trimester, a pregnant 38 y/o F has numbness in both hands, particularly thumb, forefinger, middle finger bilaterally. Dorsal part of hand unaffected. Arms ache in the morning from shoulders to hands. Diagnosis: (3x)
MEDIAN NEUROPATHY AT THE WRIST
An IV meth user develops severe back pain, followed after several days by bilateral lower extremity weakness/sensory loss, bladder incontinence, low grade fever, tenderness to percussion over the 2nd and 3rd lumbar vertebrae, paraparesis and loss of sensation to light touch and pinprick in both legs, buttocks & sacral region. (3x)
SPINAL EPIDURAL ABSCESS
What chemo agent is most commonly assoc with distal sensory polyneuropathy? (3x)
CISPLATIN
Pt w/ episodes of severe, intermittent, lancinating pain involving the posterior tongue and pharynx, w/ radiation to deep ear structures. Triggered by swallowing of cold liquids and talking. Workup: normal. Dx? (2x)
GLOSSOPHARYNGEAL NEURALGIA
Contralateral loss of pain and temp sensation with motor paralysis and proprioception loss on the other. Dx? (2x)
BROWN-SEQUARD SYNDROME (HEMISECTION)
Subacute combined degeneration of the posterior column of the spinal cord is associated with a deficiency of: (2x)
VITAMIN B12 DEFICIENCY
Which of the following is the most effective treatment of blepharospasm? (2x)
BOTULINUM TOXIN
Pt c/o progressive weakness of several days. Exam + for generalized weakness and absent reflexes. Nerve conduction studies show slowing of velocities. Dx? (2x)
ACUTE POLYNEUROPATHY
65 yo pt with progressive weakness, worse when squatting and standing from a chair. C/o decreased strength in right hand. On exam, prominent weakness of the quadriceps bilaterally and on opposition of the thumb in the right hand. Atrophy of foreman muscles with normal DTRs. No other weakness noted on exam. Sensory exam normal. ROS negative. Labs show normal CK and neg for anti-transfer RNA synthase antibodies (Jo1). What is the most likely dx? (2x)
MYOTONIC DYSTROPHY
30 y/o develops pain behind left ear. The following day pt complains of numbness on the L side of the face, tearing from L eye, and discomfort with low frequency sounds. Exam shows L facial weakness, but no sensory deficit. Likely diagnosis: (2x)
IDIOPATHIC BELL’S PALSY
One month after a MVA, a 21y/o co persistent pain in the left shoulder and arm, with sharp pain radiating into the left thumb. Exam shows weakness of the biceps. The biceps reflex on the left is absent. The most likely diagnosis is? (2x)
C-6 RADICULOPATHY
Pt c/o unpleasant aching and drawing sensations in calves and thighs associated with a crawling feeling, forcing him to move legs, bringing transient relief. Sxs worsened by fatigue. Exam nl. Best med tx? (2x)
PERGOLIDE (FOR RESTLESS LEG SYNDROME)
Severe spasms and rigidity of limbs intermittently and later more persistent/continuous: (2x)
ANTIGLUTAMIC AND ANTIDECARBOXYLASE ANTIBODIES (anti- GAD) ANTIBODIES
Weakness in limbs 2 weeks after a viral gastroenteritis. Weakness in UE/LE, absent DTRs. Spinal fluid shows no cells and elevated protein. EMG shows slow conduction velocity, prolonged distal motor latency, and conduction block. (2x)
ACUTE INFLAMMATORY POLYNEUROPATHY
2 years after MVA with rear-end collision, pt develops BUE weakness with some muscle wasting, loss of DTRs in arms, loss of sensation to pain and temp in neck/arms/shoulders, intact sensation to touch. Most likely cause? (X2)
SYRINGOMYELIA
Which of the following is the most effective treatment of spasmodic torticollis? (x2)
BOTULINUM TOXIN
72 yo with profound sensory ataxia with loss of vibratory sensation and cognitive issues with irritability and somnolence. Nutritional deficiency?
COBALAMIN
Source of pain that is primarily central (non-nocioceptive)?
FIBROMYALGIA
Exam findings suggests L5 radiculopathy in pt with back pain and foot drop?
WEAKNESS OF ANKLE INVERSION
35yo gets blurry vision, drooping eyelids, and difficulty swallowing. Weakness of bulbar muscles. What caused this?
BOTULINUM
Which of the following is most likely to reduce pain in postherpetic neuralgia
CAPSAICIN
53 y/o w/ insidious onset of blurred vision, diplopia x1 day, ptosis, CN6 palsy, unreactive pupils, hoarse voice, dysarthria, weak neck muscles. EMG - inc amp with repetitive nerve stimulation. Dx?
BOTULISM
Dx for 45yo woman w/ pins & needles feeling in hand at night and upon awakening
CARPAL TUNNEL SYNDROME
Pt with chronic muscle wasting in both UE, loss of light touch, pain, and temperature sensation in shoulders, upper arms, and back, and painful paresthesias over the same distribution, diagnosis?
SYRINGOMYELIA
103.1 F and was tx for UTI. Current exam: normal CN & sensory, minimal R leg weakness, brisk DTR and musculocutaneous reflexes throughout, and equivocal plantar reflex on L. R toe is downgoing. Hx of several episodes of transient neurological deficits that resolved spontaneously after a few days. Her spinal fluid is most likely to show what?
PROTEIN: 50MG, + OLIGOCLONAL BANDS, NUCLEATED CELLS: 10
68 y/o w/ pain in buttocks while walking, shooting down legs, w/ weakness and numbness. Relieved by sitting, pain persists with standing. Dx?
LUMBAR SPINAL STENOSIS
Where is the lesion when a picture of a female patient with ptosis is shown?
SUPERIOR CERVICAL GANGLION
T2 MRI figure in pt with cervical myelopathy. Most consistent with what dx?
DEGENERATIVE CERVICAL SPONDYLOSIS
New-onset back pain after shoveling - left paraspinal muscle spasm, negative straight leg raise, reflexes symmetric, no weakness, no sensory deficit. Management?
CONSERVATIVE (BED REST) WITH NSAIDS
50 y/o M w/ acute neck pain radiating down L arm, gait problems, urinary incontinence. What test should be ordered?
MRI OF C SPINE TO R/O CORD COMPRESSION
Horner’s syndrome is characterized by?
MIOSIS, PTOSIS, AND ANHIDROSIS OF FOREHEAD
First step in the management of acute myasthenic crisis:
MECHANICAL VENTILATION
Pt c/o pain when walking that radiates from lower back and is severe in the calves. Pain relieved by stopping for a couple of minutes, then resuming. No sensory or motor deficits. Test most likely to yield Dx?
VASCULAR EVALUATION OF LOWER EXTREMITIES
Fall from a ladder with persistent back pain and inability to void. B/l leg weakness, decreased pinprick in sacral and perianal area. Dx?
CAUDA EQUINA COMPRESSION
35-year old pt with new onset of numbness and tingling in the legs. The pt complains of a band-like sensation around the mid chest and reports episodes of urinary incontinence. Which of the following tests should be ordered next?
MRI OF THE SPINE
Fluctuating aching pain in lower back, buttocks, and sciatic distribution elicited by standing or walking, and relieved by sitting with numbness in a similar distribution, loss of ankle reflexes: what dx?
SPINAL STENOSIS
A young pt w/ a few days of progressive weakness and numbness of both legs and feet after recovering from a flu-like illness. Exam: weakness and loss of sensation to all sensory modalities below the middle of the thorax. DTR: brisker on the lower extremities, plantar reflexes are extensor. Pt has had several episodes of urinary incontinence. Other neuro exam and vital: normal. LP: 23 mononuclear cells, protein level: 37mg/dl, and normal glucose. Dx:
ACUTE TRANSVERSE MYELITIS
55 y/o M presents w/ hx of weakness and clumsiness. Symptoms began several months earlier with difficulty buttoning his clothes, getting the car keys in the ignition, and performing other fine motor tasks. He noticed that the muscles in his arm and forearm twitched under the surface, and cramped easily. Over the past few months his arms have continued to weaken and lose muscle mass. On exam, he has diffuse wasting and weakness of BUE, fasciculations, slight spasticity on arms and legs, and hyperreflexia with extensor plantar responses. Sensory, coordination, and CN exams are normal. The underlying pathological process affects neuronal bodies in which of the following structures?
ANTERIOR HORN OF THE SPINAL CORD, MEDIAL BRAINSTEM, AND PREROLANDIC CORTEX
13 y/o M w trouble keeping up w P.E. class. On exam: symmetric weakness in legs/ arms, worse in proximal muscles, most prominent in quadriceps/hamstrings. Both calves enlarged, painful w exercise. Serum creatine kinase level is 13,000. Muscle bx reveals abnormalities in dystrophin protein staining. Pattern of inheritance is?
X-LINKED
A hyperextension lesion of the shoulder resulting in weakness of abduction, internal rotation, flexion, and adduction of the extended arm most likely includes which nerve roots?
C5, C6