Neurotransmitter drugs

Question 1

Metyrosine

Answer 1

Indication: hypertension
Mechanism: competitive inhibition of tyrosine hydroxylase (converting Tyr to DOPA)

Question 2

Reserpine

Answer 2

Indication: Hypertension
Mechanism: Inhibits VMAT uptake of monoamines (into vesicle)

Question 3

Bretylium

Answer 3

Indication: Ventricular Arrhythmia
Mechanism: Inhibit action potential generation, and ca dependent synaptic vescicle fusion

Question 4

Cocaine

Answer 4

Indication: Analgesia in surgery
Mechanism: blocks monoamine reuptake

Question 5

Amphetamine or Ephedrine

Answer 5

Indication: Narcolepsy, ADHD
Mechanism: Reverse monoamine reuptake transporters (Monoamines now leaking into cleft in Ca independent manner)

Question 6

Naloxone, Naltrexone

Answer 6

Indication: Opioid overdose/ dependence
Mechanism: Non-peptide blockers of opoid receptors in CNS

Question 7

SSRIs

Answer 7

indication: depression/ anxiety
Mechanism:Selective inhibition of serotonin reuptake transporter

Question 8

ACE inhibitors (Lisinopril)

Answer 8

Indication: hypertension
Mechanism: Inhibits peptide cleavage of angiotensin I to II

Question 9

Phenylephrine

Answer 9

Indication: Hypotension during surgery
Mechanism: direct agonist of adrenergic receptor

Question 10

MAO inhibitors

Answer 10

Indication: Depression
Mechanism: Blockade of cytoplasmic metabolism of monoamines

Question 11

L-DOPA

Answer 11

Indication: Parkinson’s disease
Mechanism: Precursor of dopamine…stimulates production

Question 12

Carbidopa

Answer 12

Indication: Parkinson’s disease
Mechanism: blocks L-DOP conversion to dopamine in periphery…keeping peripheral neurons from producing too much dop and norepi

Question 13

Tyramine

Answer 13

Indication: from diet
Competes with Norepi for transport into synaptic vesicle
contraindication: increase in cytosolic norepi can lead to reversal of reuptake transporter, and lead to hypertensive crisis from too much vasoconstriction by norepi