Neuromuscular Relaxants Flashcards
Non-depolarizing competitive antagonists of NM receptors list
Pancuronium
Vercuronium
Mivacurium
Rocurium
Non depolarizing NM relaxants clinical uses
Adjuvant to anesthesia during surgery, relaxation of chest during mechanical ventilation
relaxation of larynx for endotracheal intubation (rorcuronium and imcuronium
Non depolarizing NM relaxants side effects
non analgesic, apnea, histamine release (mivacurium), muscarinic blockade (pancuronium, rorcuronium)
Non depolarizing NM drug interactions
inhalation anesthetics (enhance effect) and antibiotics (enhance effect)
Non depolarizing NM antidote
AchE inhibitors (neostigmine) muscarinic antagonists (glycopyrrolate)
elimination and half lives of non depolarizing NM relaxants
Pancuronium: renal (long t1/2)
Vecuronium: renal (some hepatic… middle t1/2)
Rorcuronium: hepatic (middle t 1/2)
Mivacurium: metabolic (short 1/2)
Succinylcholine type and MOA
type: depolarizing NM relaxaxant
MOA: binding to Achetylcholine receptor… opening it and keeping it open
(phase II membrane becomes repolrized but receptor insenetive to Ach
see fasciculations followed by flaccid paralysis
Succinylcholine uses
endo tracheal intubation… suppression of muscle contraction during electro shock
Succinylcholine side effects
non analgesic, apnea, muscle pain (fasciculations)
Succinylcholine antidote
phase 1: time
phase 2: AchE inhibitors
Bacloffen type, MOA, RX
spasmolytic drug
Gaba agonist
Rx: spinal spasticity and MS
Bacloffen side effects
Drowsiness
Benzodiazepines (diazepam) type, MOA, Rx
spasmolytic drug
pos allosteric modulators of gaba receptors
Rx: spinal spasticity, MS
Benzodiazapenes side effect
sedation/ drowsiness
Tizanidine type, MOA, Rx
alpha2 adrenergic agonist (promoting inhibition in spinal chord)
Rx: spinal spasticity, MS
