Neuroscience Flashcards
Internal Auditory Meatus (IAM)
Hole through the petrous temporal bone.
Contains the 7th and 8th cranial nerves.
CPS-Cerebello-Pontine-Angel
Location between the IAM and the Cochlear Nucleus.
Contains the 7th & 8th cranial nerves
Bi-polar disorder
Type I- Manic
Type II-Hypomania
Type I= w/ or w/out depression episodes
Type II=episodes of milder mania ALWAYS associated w/ depression bouts NOT long enough in duration to be major depression–not 2 weeks.
Sternocleidomastoid Muscle
Medial 3rd of clavicle, the origin=manubrium of sternum
Sweeps up and inserts into the mastoid process
Function=flexes the neck
Anatomy vs. Phsiology
Study of structures of organisms and relations to their parts
Vs
Science dealing w/ functions of living organisms or their parts, way which bodily part functions.
Dysphagia
Difficulty swallowing
The first 2 stages, of 4, for “normal” swallowing.
1st-Oral Preparatory Phase
2nd=Oral Transport Phase
1st-labial seal. Tongue to Velum contact. Bolus is formed
2nd-posterior tongue depression; bold X squeezes against the palate, the arytenoid cartilages rock forward and respiration stops
The last 2 stages (of the 4) for “normal” swallowing.
3rd-Pharyngeal Phase
4th-Esophageal Phase.
3rd-closure of velopharyngeal, hyo-laryngeal elevation, epiglottic inversion, airway closure, base of tongue retraction, posterior pharyngeal wall contraction.
4th-bolus moves faster through upper 1/3; moves slower through the aortic arch. Kids= 6-10 seconds
Adults= 8-20 seconds
Scarpas’ Ganglion
Collection of vestibular Afferent neurons connect HCs and are the 1st order of neurons of the vestibular nerve.
Vestibulospinal Tract
- Medial-Bilateral pathway (control neck and trunk)
2. Lateral-Ipsilateral pathway (control limbs)
Ampullae
Bulge near base of the semi-circular canals.
Cupula
Gelatinous interior. Hair cells sit on top of the crista
Otoliths Organs
Saccule=vertical acceleration
Utricle=horizontal acceleration
VSR-Vestibulospinal Reflex
Helps maintain postural control muscle throughout body and are constantly changing tension to maintain this posture.
VOR-Vestibuloocular Reflex
Stabilize retinal images during head movement–the eyes move in direction opposite of the head rotation.
VNG-Videonystagmography Testing
Exploit the VOR–tests stress VOR
Look for Nystagmus, the rhythmic beating of the eyes
VEMP-Vestibular Evoked Myogenic Potential Testing
Soon-motor reflex; muscle action induced by sound stimulation. Uses high level sounds to stimulate and reflect the saccule. The saccule reacts as if to an impact or sudden movement.
VNG Testing
- ) Occulomotor Testing=patient must eye track light source as it moves
- ) Postional/Postural Testing=patient is placed in series of positions.
- ) Caloric Testing=hot/cold H20, or air, inserted into the ear canal .
The 3 Vestibular Organs
- Saccule
- Utricle
- Semi-circular Canals
The 4 separate nuclei of the SOC
- Lateral Superior Olive (LSO)
- Medial Superior olive (MSO)
- Trapezoid Body
- Pre-Olivary Nuclei
2 mechanisms combined to give information.
- ITD-Interaural Time Difference—for low frequency sounds
2. ILD-Interaural Level Difference–for high frequency founds
Generalized Anxiety Disorder
Persistent heightened sense of anxiety. More than 6 months to diagnose NOT marked by panic attacks.
Phobia
Oversized reaction to environmental stimulus by activity sympathetic NS
Obsessive Compulsive Disorder (OCD)
Obsession=intransigence thoughts “bad” & feelings, impulses lead to anxiety
Compulsions=repetitive actions or thoughts used to mitigate anxiety
Humeral
Influence body through ENDOCRINE changes
Visceromotor
Influence body thru changes in sympathetic and parasympathetic nervous systems.
Somatic
Influence body changes through primarily SKELETAL muscle
3 general functions of hypothalamus
- ) Humeral
- ) Visceromotor
- ) Somatic
2 types of bipolar disease
Type I=Manic Episodes-characterized by w/ or w/out depression episodes
Type II- Characterized by Hypomania episodes milder mania. Always associated w/ depression bouts. Not lasts 2 weeks though.
Benzodiazepines
Influence GABA (Gamma Aminobutyric Acid). Powerful inhibitory NT. Ex. Valium-affect entire brain-effective for acute anxiety outs/attacks.
Diathesis-Stress hypothesis
Genetic predisposition to a disorder overactive HPA system from lack of glucocortoid receptors in hippocampus
Schizophrenia
Loss of reality. Disruption of thoughts perception and mood.
Delusions. Hallucinations. Disorganized Speech.
Disorganized behavior. Memory Impairment.
Influence of amygdala on HPA
Sensory input coming from neocortex, goes to amygdala. The amygdala stimulates the hypothalamus if stimuli induces fear response.
HPA Is activated.
Schizophrenia
Loss of contact w/reality. Disruption of thoughts, perception and mood. Delusions Hallucinations. Decrease emotion expressed. Memory impairment. Disorganized speech/hearing
Hard initiate goal–directed behavior
Auditory Cortex Location
Deep in temporal lobe @ lateral sulcus. Brodmann’s 41 & 42 areas @ the superficial part.
2 pathways of the olive cochlear efferent systems
Medial-inhibits elector motility of OHCs depolarization hindered
Lateral-no due IPSPs in Afferent dendrites of spiral ganglion neurons.
What does the cochlear amplifier do?
Enhances BM displacement @ CF to stimulus
TC-Tuning Curve
The envelope of the thresholds required for provoking response across all the frequencies. Divided into 2 sections: tail and tip
Inferior Colliculus (IC)
Functions not totally understood; appears to refine frequency processing of CN and binaural processing of SOC and may aid in sound localization.
Cochlea’s Primary job
Transducer auditory acoustic- electrochemical signal for the brain.
Otocnia
Ca+ carbonate crystals that sit atop gelatinous layer and provide inertial mass not in semi-circular canals.
Macula
Surface of otoliths that contain hair cells
VCR-Vestibulocollic Reflex
Muscle action to stabilize head following impact or sudden movement
Cerebellum in VOR
Crucial motor learning the small instinctual movements made in eyes to compensate for movement of the head.
Balance input- 3 sources
- ) Vestibular End Organ
- ) Visual System
- ) Somato-Sensory/Proprioceptive System
Caloric Testing-VNG Testing
Stimulate horizontal SCC COWS-direction of beat of nystagmus
COLD=Opposite. WARM=Same
Paresis
Muscle weakness & minor paralysis loss of excitatory action on D1 receptors
Rigidity
A product of lack of excitation and inhibition. Inability to contract main muscle & inability to inhibit antagonist muscle
Basal Ganglia
Sits deep w/in cerebral hemispheres under cortex layers.
- ) Caudate Nucleua
- ) Putamen
- ) Substantia Nigra
- ) Subthalamic Nuclei
- ) Globus Pallidus
Supplemental Motor Cortex
Pre motor extends deep & becomes supplemental motor cortex (Broadmanns’ Area 6)
Chorea
Slow involuntary movements of face and distal limbs.
Parts of the Corpus Callosum
Primary Sensory Cortex + Primary Motor Cortex + Supplemental Motor Cortex
Strategy vs. Execution vs Tactics
Goal of movement & how to achieve the goal. Associate areas visual & BG & auditory cortices
VS
Activation of specific lower motor neurons to contract appropriate muscles. Brain stem & SC
VS
Sequence of muscle contractions needed to c/w the strategy. Motor cortex & cerebellum
Upper Motor Neurons
VS
Lower Motor Neurons
From Motor Cortex or Brainstem
VS
Motor neurons on SC or connecting brainstem/SC to muscle effectors
2 Spinal Cord Pathways
- ) Lateral-voluntary movement of distal muscles (originate in the cortex)
- ) Ventromedial-heavily involved in postural control (originated in Brainstem needed to maintain in posture & balance.
Primary Motor Cortex
Responsible for volition all control of motor systems. precise movements Lose contralateral side if damage to this.
Prefrontal Cortex
- large #s of efferent and Afferent pathways
- defined one’s personality & congnition
- highest -order processing takes place
- inputs to motor cortex w/ decisions about what actions need to be done.
Parkinson’s Disease
Substantia Nigra degenerates loss of dopamine release to the corpus striatum. Muscle tremors, rigidity, initiating movements & postural disturbances.
Tremors
Uncontrollable movements loss of inhibitory action on D2 receptors
Superoxide
Superoxide Dismutase
O2 w/ additional unpaired e-, key intermediary molecule e-Transport Chain (eTC). This excess leads to break down of DNA, cell membrane and triggers apoptosis.
Catalyze O2- +2H+=H2O2, then catalyze again to H2O
Multiple Sclerosis (MS)
De-myelinated disease of CNS & PNS at 20-40 hold. Auto-immune reaction. Plaques of de-myelinated are visible in MRIs.
Amyotrophic Lateral Sclerosis (ALS)
Progressive atrophy of the Upper and Lower Motor System Neurons Etiology=unknown
Affective Neuroscience
Study of neural basis of emotions and moods.
Emotional expression and emotional experiences.
Kluver-Bucy Syndrome
Results temporal lobe lesions, include the amygdala.
Hyper-sexuality. “Flat emotion”
Decrease in fear & aggression
Aggression
NOT an emotion. Behavior manifestation of the anger emotion
2 parts= 1.) Predatory-for purpose of obtaining food. Little vocalization or activation of sympathetic NS-stimulated hypothalamus (Lateral)
2.) Affective- showy aggression to intimidate. MUCH vocalization & sympathetic NS (e.g. Cat hair stands up when see dog)
James-Lange Theory of emotion
- Reaction to Brain path=emotion response to physiological changes in body. Body Changes lead to emotion
Cannon-Bard Theory of emotion
Brain, then to Reaction. Experience separate from expression inputs to thalamus drive emotions
Papez Circuit
Bi-directional “emotion system” medial wall of brain, links cortex w/ hypothalamus
Fornix
Bundle of axons leave the hippocampus to the hypothalamus
Paul Broca’s Limbic Lobe
Form ring around brain stem and corpus Callosum on brain’s medial walls.
Neural basis of aggression
Amygdala (also orbito-frontal cortex & anterior cingulate cortex also involved)
Anxiety and 5 types
Symptom sympathetic system activation. Brain perceives things as stressors.
- ) Panic Disorder. 2.). Agoraphobia
- ) Generalized Anxiety Disorder 4.) Phobias
- ) Social Phobia/Social Anxiety