Neuroplasticity Part 2 Flashcards
Who compared changed in cortical motor representations post Stroke?
Nudo
What were results for spontaneous group in nudos post-stroke study?
Hand and digit cortical areas surrounding the lesion decreased compared to control
What were results for rehab group in Nudos post-stroke study?
Hand and digit cortical areas did not differ from control
Nudo suggests rehab training prevented
loss of cortical area.
What is another change that occurs after cortical lesion?
modifications of intracortical pathways.
What was Jeff Kleims Novelty intervention?
what did it do?
Use of drugs to promote plasticity
increased cortical area
In using drugs for plasticity, what is the only way it worked?
if accompanied by motor skill training.
What happened to animals who received TMS
they improved faster and reached a higher end point.
What happened to brain areas around infarct in animals who received TMS?
They were preserved with change in cortical maps.
What did Frackowiak + Chollert do?
Used PET to look at changes in regional blood flow.
What was result of Frackowiak + Chollert’ study?
Showed increased bloodflow (activity) in ipsilateral side during recovered finger mvmt. Showed opposite side took over.
What are 10 Principles of Experience in dependent neural plasticity.
- Use it or lost it
- use it improve it
- Specificity
- Repitition Matters
- Intensity Matters
- Time matters
- Salience Matters
- Age Matters
- Transference
- Interference
Spontaneous recovery after stroke is .
who thought this?>
Highly Variable
Kramer
Recovery of motor function post-stroke cannot be directly explained by ____.
What else has influence?
lesion type, location, or extent.
genetics
a protein growth factor involved in neuroplasticity and neuroprotection
and is identified as a key mediator of motor learning after stroke.
Brain derived Neurotrophic factor
BNDF
