Neuropharmacology Flashcards

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1
Q

What primary issues affect success of a drug

A

Issues related directly to disease: understanding the disease and defining correct treatment target

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2
Q

What secondary issues affect success of a drug

A

Related directly to therapeutic attempt. Importance of reaching target, minimise adverse affects, manage resistance

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3
Q

What causes Parkinsons’ disease?

A

Deficit in dopamine

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4
Q

What problems are presented when attempting to treat Parkinsons with administration of dopamine?

A

Neither dopamine or precursor (L-dopa) can reach brain

Administrating L-dopa orally leads to conversion to dopamine outside the brain–> vomiting

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5
Q

Solution to problems of treating Parkinsons?

A

Provide L-dopa combined with inhibitor of enzyme which doesn’t have access to brain
therefore, only converted in the brain

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6
Q

What causes shizophrenia

A

Increase in dopamine

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7
Q

Treatment option for schizophrenia?

A

Provide dopamine receptor antagnosis which block dopamine receptors

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8
Q

Why are there adverse effects to using neuroleptic drugs?

A

As well as blocking dopamine receptors, also block other receptors- not specific

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9
Q

What causes depression?

A

Insufficient levels of serotonin and noradrenaline

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10
Q

How do antidepressants work

A

Inhibit reuptake of monoamine (serotonin and noradrenaline)

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11
Q

What causes adverse effects of antidepressants?

A

Have affinity for histamine H1 receptors, muscarinic cholinergic receptors, adrenoreceptors so have many adverse effects

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12
Q

What is main aim of addiction treatment?

A

Reduce withdrawal symptoms

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13
Q

Effect of ecstacy on nervous system?

A

Increases monoamine release

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14
Q

Effect of cocaine on nervous system?

A

Inhibits monoamine uptake

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15
Q

Effect of ket on nervous system?

A

Glutamate receptor antagonist

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16
Q

Effect of nicotine on nervous system?

A

Nicotininc cholinergic receptor agonist

17
Q

Why may drug targets in brain never be reached?

A

Intrinsic or acquired overexpression of multidrug transporters at BBb restrict brain uptake of drugs