Neuropharmacology Flashcards
Autonomic Nervous System
self-governing or automatic, involuntary, adrenergic, and cholinergic fibers (effects are opposite)
Sympathetic Nervous System
“fight or flight” - pupils dilates
I sympathize with the person being chased by the bear
Parasympathetic Nervous System
“rest and digest” - pupils and airway constrict
Adrenergic receptors
sympathetic
Norepinephrine (NE)
Cholinergic receptors
parasympathetic
acetylcholine (Ach)
Sympathetic and pupils
dilates pupils
Parasympathetic and pupils
constricts
sympathetic on airways
bronchodilation
Parasympathetic on airways
bronchoconstriction
Sympathetic on heart
increase heart rate, a-v conduction, ventricular contractility
Parasympathetic on heart
decrease heart rate, a-v conduction
Sympathetic on blood vessels
vasoconstriction, increase BP
Parasympathetic on blood vessels
vasodilation, decrease BP
Sympathetic on GI tract
increase blood glucose, digestion, decrease blood flow, tighten sphincters
Parasympathetic on GI tract
stimulates digestion, absorption, increase GI tract activity, relax sphincter
Sympathetic on bladder
contracts sphincter, relaxes detrusor
Parasympathetic on bladder
relaxes sphincter, contracts detrusor
Adrenergic
sympathomimetics
flight or fight
Adrenergic blockers
sympatholytic drugs
blocks flight or fight
Cholinergic
parasympathomimetic
rest and digest
Anticholinergics
parasympatholytic
blocks rest and digest
Medication should be more
focused on one system
Muscarinic
cholinergic agonist that works on target organs
GI
Bethanechol
MOA: direct-acting cholinergic agonists
Urinary retention - beth has to pee
Atropine
dilation of eyes
treat bradycardia
