Neuropharmacology

Question 1

What transports and regulates dopamine?

Answer 1

VMAT2

Question 2

Name the 5 main targets for psychotropics (affects behavior/mood)

Answer 2

Serotonin (5-ht)
Histamine
Norepinephrine
Dopamine
Acetylcholine

Question 3

What is the role of 5-HT in antidepressants?

Answer 3

Allows serotonin to stay in the synapse longer
Blocks the reuptake

Question 4

5-HT 1 and 2 families involved with what?
A. Anxiety
B. Hypnotic
C. Memory
D. Muscle relaxer

Answer 4

Anxiety

Question 5

Name the 4 major dopamine pathways (DA)

Answer 5

Mesolimbic
Mesocortical
Nigrostriatal
Tuberoinfundibular

Question 6

Antagonists at Mesolimbic pathway does what?

Answer 6

Reduce psychosis

Question 7

Antagonists at mesocortical pathway does what?

Answer 7

worsens negative symptoms and cognition

Question 8

Antagonists at nigrostriatal pathway does what?

Answer 8

Cause movement disorders.
Affects the extrapyramidal system

Question 9

Antagonists at tuberoinfundibulnar pathway does what?

Answer 9

• decrease signal to anterior pituitary gland
• increase prolactin

Question 10

DA receptor:
D1 & D5 targets what?

Answer 10

ADHD

Question 11

DA receptors:
D2 and D4 targets what ?

Answer 11

psychosis

Question 12

DA receptors:
D3 targets what?

Answer 12

Parkinsons

Question 13

What does the GABA receptors do?

Answer 13

shuts off switch/ like “brakes”

Question 14

GABA receptors and subtypes:
GABA(a1) targets what?

Answer 14

sedative/hypnotic,reinforcing

Question 15

GABA receptors and subtypes:
GABA(a2) and (a3) targets what?

Answer 15

Anxiolytic (reduce anxiety)
Anticonvulsant (reduce seizures) (A2)

Question 16

GABA receptors and subtypes:
GABA(a5) targets what?

Answer 16

learning and memory

Question 17

GABA receptors and subtypes:
GABA(b3) targets what?

Answer 17

Respiratory drive
Hypnotic

Question 18

GABA receptors and subtypes:
GABA(B) targets what?

Answer 18

muscle relaxant