Antipsychotics Flashcards
Which receptor do antipsychotics target?
D2 antagonism
What are the difference between typical and atypical antipsychotics?
Atypical antipsychotics antagonizes D2 and 5-HT2
Identify class:
Phenothiazines
Thioxanthenes
Butyrophenones
Dibenzoxazepines
Dihydroxyindole
Diphenylbutlpiperidine
Typical (conventional) antipyschotics
MOA:
Typical antipsych
Blocks D2 mesolithic area
Potent DA receptor inhibitor
Identify Class:
Clozapine
Risperidone
Olanzapine
Quietiapine
Ziprasidone
Arirazole
Cariprazine
Lurasidone
Lumateperone
Atypical Antipysch (what we use today)
MOA:
atypical antipsych
DA antagonists - mainly D2 (not recommended for pts with EPS/movement disorders)
Serotonin antagonists - mainly 5-HT2a (helps reduce anxiety)
Difference between Parkinsons & Schizophrenia?
Parkinson: not enough DA
Schizophrenia: too much DA
Which agents would you prescribe for a parkinson’s patient?
Anticholenergic (benztropine)
Amantadine (increase DA)
Which atypical antipsychotics drug hs the highest risk for weight gain?
Olanzapine
Which atypical antipsychotics drug has the lowest risk for weight gain?
Ziprasidone
Which atypical antipsychotic drug is the greatest risk in pts with QTc risk?
Ziprasidone
(D/C if QTc >500msec)
Which atypical antipsychotic is the least risk in pts with QTc?
ariprazole and lurasidone
Which atypical antipsychotic agent is recommended with food?
Lurasidone (increase absorption b 200%)
Which atypical antipsychotic agent is the only transdermal antipsychotic & can be taken sublingually too?
Asenapine
which antipsychotic combination drug helps lower compulsive behaviors (eating) and help lose weight from olanzapine?
Olanzapine/Samidorphan
