Neuropharma

Question 1

Non Adrenergic Non Chollinergic NT

Answer 1

Neuropeptide Y
Vasoactive Neuropeptide
Substance P

Question 2

Impulse causes increse permeablity of ___ Ions

Answer 2

Ca

Question 3

Sypathetic Anatomy Roots

Answer 3

T1-L5

Question 4

Sypathetic Location of Ganglia

Answer 4

Near the Cord

Question 5

Sypathetic Receptors
Pregangionic
Postganglionic

Answer 5

Pre - Nicotine

Post - a, B, D

Question 6

Figh fligh fright

Answer 6

Sympathetic

Question 7

Source of the Catecholamine

Answer 7

Adrenal Medulla

Question 8

Inhibits storage of NE in vesicles

Inhibit NE and dopamine Response

Answer 8

Reperine

Question 9

Decrease in this NT causes depression with suicidal tendencies

Answer 9

NE

Question 10

Drugs that inhibit release of catecholamines

Answer 10

Guanethidine

Bretylium

Question 11

Drugs that stimulate sypathetic response/release

Answer 11

Ampethamine

Metampethamine

Question 12

Tyramine inhibits

Answer 12

MAOI

Question 13

Receptor responsible for vasoconstriction

Answer 13

a1

Question 14

Adrenergic receptor of the heart

Answer 14

B1

Question 15

GI tract Sympathetic receptor

Answer 15

a2,B2

Question 16

Parasympathetic Receptor of the heart

Answer 16

M2

Question 17

Sympathetic receptor of skeletal, bronchial and Uterine muscles

Answer 17

B2

Question 18

Adrenergic agonist producing sympathetic response by causing an increase in the concentration of NE in the sypathetic cleft

Answer 18

Inirect Acting Sympathomimetics

Question 19

3 natural Catecholamines

Answer 19

Epinephrine
Norepinephrine
Dopamin

Question 20

Predispose the drug to the action of Catecholamine transferase

Answer 20

Catechol

Question 21

Common Catecholamine metabolites

Answer 21

Metanephrine

Vanilyl Mandelic Acid in pheochromocytoma

Question 22

Afinity of catecholamines to a and B receptors:
Dec concentration stimulates ____receptors
Inc conc stimulates ____receptors

Answer 22

Dec –> B

Inc –a

Question 23

First line drug used for anaphylactic shock and perfomance of ACLS

Answer 23

Epinephrine

Question 24

first line drug used for SEPTIC shock

Answer 24

NorEpinephrine

Question 25

Receptor affinity of NE

Answer 25

a1 and B1 only.

Question 26

Doses of Dopamine and effects Vasodilation ___ ug/kg/min Vasoconstricion ___ug

Answer 26

Vasodialte 1-3ug D1 receptor | Vasoconstric >5ug a1

Question 27

Non selective B agonist

Answer 27

Isoprotenerol

Question 28

Selective B1 agonist

Answer 28

Dobutamine

Question 29

a2 selective agonist

Answer 29

Clonidine, Methyldopa --> Central Acting

Question 30

a1 selective agents

Answer 30

-ephrine, -edine, -zoline

Question 31

Drug that Stimulates B1 and B2 receptors

Answer 31

Salbutamol/Salmeterol

Question 32

Cardiac stimulant used in Cardiogenic shock or Acute Heart Failure

Answer 32

Dobutamine

Question 33

Dobutamine Classification

Answer 33

Selective B1 Agonist

Question 34

First line in Asthma management

Answer 34

Inhaled B2 agonist

Question 35

Side Effects of B2 Agonists

Answer 35

Hypokalemia Muscle Tremors Tolerance Tachycardia

Question 36

Side effect of Clonidine

Answer 36

sedation depression rebound HPN

Question 37

A2 selective Agonist for pregnants

Answer 37

Methyldopa

Question 38

Side effects Methyldopa

Answer 38

Drug induced lupus hepatotoxicity sedation

Question 39

Give 1 a1 selective agent

Answer 39

Phenyleprhine - decongestants

Question 40

Centrally Acting Sympathomimetics

Answer 40

``` Amphtetamine Phtermine Mephenidate PPA Ephedrine ```

Question 41

Clinical use of Centrally active sympathomimetics

Answer 41

Anorexients - Appetite suppresants | ADHD

Question 42

Adrenergic Antagonists classification and examples

Answer 42

Alpha blockers - selective and non selective

Question 43

Causes irreversible inhibition of a1 and a2

Answer 43

Phenoxybenzamine

Question 44

Clinical Uses of Phenoxybenzamine

Answer 44

Presurgical management of HPN in pherocromocytoma Management of Raynaud's phenomenon Mgt of Carcinoid syndrome (facial flaring)

Question 45

causes reversible inhibition of a1 and a2

Answer 45

Phentolamine

Question 46

Clinical Uses of Beta blockers. give example

Answer 46

``` Metropolol, Propanolol Uses: 1st line anti HPN Anti arryhtmias Prophylaxis for angina pectoris Management for STABLE CHF glaucoma control sympathetic symptoms of hyperthyroidism ```

Question 47

Side effects of Beta Blockers

Answer 47

rebound tachycardia heart block decreases exercise tolerance

Question 48

Contraindicated in Beta blockers

Answer 48

Heart block Unstable CHF Bronchial Asthma, COPD

Question 49

Parasympathetic Muscarinicreceptors location and response

Answer 49

M2 Heart Bradycardia M1 Vagus nerve Stimulation;add secretion M3 Glands endothelium Smooth Muscles - vasodilation stiumation and contracion, increase secretion

Question 50

Direct Acting cholinomimetics

Answer 50

Choline esters - Actch, Metacholine,betanicol | Alkaloids - pilocarpine, muscarine

Question 51

Clinical uses of Direct Acting Cholinomimetics

Answer 51

Glaucoma Urinary Retention Smoking addiction

Question 52

Used to diagnose Myasthenia Gravis

Answer 52

Edrophonium (Tensilon)

Question 53

Antidote for Curare poisoning

Answer 53

Neostigmine

Question 54

Antidote for Atropine Toxicity

Answer 54

Physostigmine

Question 55

Cholinergic Antagonists example

Answer 55

Atropine

Question 56

Uses of cholinergic antagonis(atropine)

Answer 56

organophosphate poisoning symptomatic bradycardia given with diphenoxylate for prevention of addiction

Question 57

Used in Parkinsonism

Answer 57

Biperiden

Question 58

Used to decrease oral secretion during anesthesia

Answer 58

atropine