Neuropharma Flashcards
Non Adrenergic Non Chollinergic NT
Neuropeptide Y
Vasoactive Neuropeptide
Substance P
Impulse causes increse permeablity of ___ Ions
Ca
Sypathetic Anatomy Roots
T1-L5
Sypathetic Location of Ganglia
Near the Cord
Sypathetic Receptors
Pregangionic
Postganglionic
Pre - Nicotine
Post - a, B, D
Figh fligh fright
Sympathetic
Source of the Catecholamine
Adrenal Medulla
Inhibits storage of NE in vesicles
Inhibit NE and dopamine Response
Reperine
Decrease in this NT causes depression with suicidal tendencies
NE
Drugs that inhibit release of catecholamines
Guanethidine
Bretylium
Drugs that stimulate sypathetic response/release
Ampethamine
Metampethamine
Tyramine inhibits
MAOI
Receptor responsible for vasoconstriction
a1
Adrenergic receptor of the heart
B1
GI tract Sympathetic receptor
a2,B2
Parasympathetic Receptor of the heart
M2
Sympathetic receptor of skeletal, bronchial and Uterine muscles
B2
Adrenergic agonist producing sympathetic response by causing an increase in the concentration of NE in the sypathetic cleft
Inirect Acting Sympathomimetics
3 natural Catecholamines
Epinephrine
Norepinephrine
Dopamin
Predispose the drug to the action of Catecholamine transferase
Catechol
Common Catecholamine metabolites
Metanephrine
Vanilyl Mandelic Acid in pheochromocytoma
Afinity of catecholamines to a and B receptors:
Dec concentration stimulates ____receptors
Inc conc stimulates ____receptors
Dec –> B
Inc –a
First line drug used for anaphylactic shock and perfomance of ACLS
Epinephrine