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Neurology > Neuropharma > Flashcards

Neuropharma Flashcards

1
Q

Non Adrenergic Non Chollinergic NT

A

Neuropeptide Y
Vasoactive Neuropeptide
Substance P

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2
Q

Impulse causes increse permeablity of ___ Ions

A

Ca

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3
Q

Sypathetic Anatomy Roots

A

T1-L5

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4
Q

Sypathetic Location of Ganglia

A

Near the Cord

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5
Q

Sypathetic Receptors
Pregangionic
Postganglionic

A

Pre - Nicotine

Post - a, B, D

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6
Q

Figh fligh fright

A

Sympathetic

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7
Q

Source of the Catecholamine

A

Adrenal Medulla

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8
Q

Inhibits storage of NE in vesicles

Inhibit NE and dopamine Response

A

Reperine

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9
Q

Decrease in this NT causes depression with suicidal tendencies

A

NE

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10
Q

Drugs that inhibit release of catecholamines

A

Guanethidine

Bretylium

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11
Q

Drugs that stimulate sypathetic response/release

A

Ampethamine

Metampethamine

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12
Q

Tyramine inhibits

A

MAOI

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13
Q

Receptor responsible for vasoconstriction

A

a1

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14
Q

Adrenergic receptor of the heart

A

B1

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15
Q

GI tract Sympathetic receptor

A

a2,B2

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16
Q

Parasympathetic Receptor of the heart

A

M2

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17
Q

Sympathetic receptor of skeletal, bronchial and Uterine muscles

A

B2

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18
Q

Adrenergic agonist producing sympathetic response by causing an increase in the concentration of NE in the sypathetic cleft

A

Inirect Acting Sympathomimetics

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19
Q

3 natural Catecholamines

A

Epinephrine
Norepinephrine
Dopamin

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20
Q

Predispose the drug to the action of Catecholamine transferase

A

Catechol

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21
Q

Common Catecholamine metabolites

A

Metanephrine

Vanilyl Mandelic Acid in pheochromocytoma

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22
Q

Afinity of catecholamines to a and B receptors:
Dec concentration stimulates ____receptors
Inc conc stimulates ____receptors

A

Dec –> B

Inc –a

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23
Q

First line drug used for anaphylactic shock and perfomance of ACLS

A

Epinephrine

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24
Q

first line drug used for SEPTIC shock

A

NorEpinephrine

25
Q

Receptor affinity of NE

A

a1 and B1 only.

26
Q

Doses of Dopamine and effects
Vasodilation ___ ug/kg/min
Vasoconstricion ___ug

A

Vasodialte 1-3ug D1 receptor

Vasoconstric >5ug a1

27
Q

Non selective B agonist

A

Isoprotenerol

28
Q

Selective B1 agonist

A

Dobutamine

29
Q

a2 selective agonist

A

Clonidine, Methyldopa –> Central Acting

30
Q

a1 selective agents

A

-ephrine, -edine, -zoline

31
Q

Drug that Stimulates B1 and B2 receptors

A

Salbutamol/Salmeterol

32
Q

Cardiac stimulant used in Cardiogenic shock or Acute Heart Failure

A

Dobutamine

33
Q

Dobutamine Classification

A

Selective B1 Agonist

34
Q

First line in Asthma management

A

Inhaled B2 agonist

35
Q

Side Effects of B2 Agonists

A

Hypokalemia
Muscle Tremors
Tolerance
Tachycardia

36
Q

Side effect of Clonidine

A

sedation
depression
rebound HPN

37
Q

A2 selective Agonist for pregnants

A

Methyldopa

38
Q

Side effects Methyldopa

A

Drug induced lupus
hepatotoxicity
sedation

39
Q

Give 1 a1 selective agent

A

Phenyleprhine - decongestants

40
Q

Centrally Acting Sympathomimetics

A 
Amphtetamine
Phtermine
Mephenidate
PPA
Ephedrine
41
Q

Clinical use of Centrally active sympathomimetics

A

Anorexients - Appetite suppresants

ADHD

42
Q

Adrenergic Antagonists classification and examples

A

Alpha blockers - selective and non selective

43
Q

Causes irreversible inhibition of a1 and a2

A

Phenoxybenzamine

44
Q

Clinical Uses of Phenoxybenzamine

A

Presurgical management of HPN in pherocromocytoma
Management of Raynaud’s phenomenon
Mgt of Carcinoid syndrome (facial flaring)

45
Q

causes reversible inhibition of a1 and a2

A

Phentolamine

46
Q

Clinical Uses of Beta blockers. give example

A 
Metropolol, Propanolol
Uses:
1st line anti HPN
Anti arryhtmias
Prophylaxis for angina pectoris
Management for STABLE CHF
glaucoma
control sympathetic symptoms of hyperthyroidism
47
Q

Side effects of Beta Blockers

A

rebound tachycardia
heart block
decreases exercise tolerance

48
Q

Contraindicated in Beta blockers

A

Heart block
Unstable CHF
Bronchial Asthma, COPD

49
Q

Parasympathetic Muscarinicreceptors location and response

A

M2 Heart Bradycardia
M1 Vagus nerve Stimulation;add secretion
M3 Glands endothelium Smooth Muscles - vasodilation stiumation and contracion, increase secretion

50
Q

Direct Acting cholinomimetics

A

Choline esters - Actch, Metacholine,betanicol

Alkaloids - pilocarpine, muscarine

51
Q

Clinical uses of Direct Acting Cholinomimetics

A

Glaucoma
Urinary Retention
Smoking addiction

52
Q

Used to diagnose Myasthenia Gravis

A

Edrophonium (Tensilon)

53
Q

Antidote for Curare poisoning

A

Neostigmine

54
Q

Antidote for Atropine Toxicity

A

Physostigmine

55
Q

Cholinergic Antagonists example

A

Atropine

56
Q

Uses of cholinergic antagonis(atropine)

A

organophosphate poisoning
symptomatic bradycardia
given with diphenoxylate for prevention of addiction

57
Q

Used in Parkinsonism

A

Biperiden

58
Q

Used to decrease oral secretion during anesthesia

A

atropine

Neurology (6 decks)

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