Neuropharma Flashcards
Non Adrenergic Non Chollinergic NT
Neuropeptide Y
Vasoactive Neuropeptide
Substance P
Impulse causes increse permeablity of ___ Ions
Ca
Sypathetic Anatomy Roots
T1-L5
Sypathetic Location of Ganglia
Near the Cord
Sypathetic Receptors
Pregangionic
Postganglionic
Pre - Nicotine
Post - a, B, D
Figh fligh fright
Sympathetic
Source of the Catecholamine
Adrenal Medulla
Inhibits storage of NE in vesicles
Inhibit NE and dopamine Response
Reperine
Decrease in this NT causes depression with suicidal tendencies
NE
Drugs that inhibit release of catecholamines
Guanethidine
Bretylium
Drugs that stimulate sypathetic response/release
Ampethamine
Metampethamine
Tyramine inhibits
MAOI
Receptor responsible for vasoconstriction
a1
Adrenergic receptor of the heart
B1
GI tract Sympathetic receptor
a2,B2
Parasympathetic Receptor of the heart
M2
Sympathetic receptor of skeletal, bronchial and Uterine muscles
B2
Adrenergic agonist producing sympathetic response by causing an increase in the concentration of NE in the sypathetic cleft
Inirect Acting Sympathomimetics
3 natural Catecholamines
Epinephrine
Norepinephrine
Dopamin
Predispose the drug to the action of Catecholamine transferase
Catechol
Common Catecholamine metabolites
Metanephrine
Vanilyl Mandelic Acid in pheochromocytoma
Afinity of catecholamines to a and B receptors:
Dec concentration stimulates ____receptors
Inc conc stimulates ____receptors
Dec –> B
Inc –a
First line drug used for anaphylactic shock and perfomance of ACLS
Epinephrine
first line drug used for SEPTIC shock
NorEpinephrine
Receptor affinity of NE
a1 and B1 only.
Doses of Dopamine and effects
Vasodilation ___ ug/kg/min
Vasoconstricion ___ug
Vasodialte 1-3ug D1 receptor
Vasoconstric >5ug a1
Non selective B agonist
Isoprotenerol
Selective B1 agonist
Dobutamine
a2 selective agonist
Clonidine, Methyldopa –> Central Acting
a1 selective agents
-ephrine, -edine, -zoline
Drug that Stimulates B1 and B2 receptors
Salbutamol/Salmeterol
Cardiac stimulant used in Cardiogenic shock or Acute Heart Failure
Dobutamine
Dobutamine Classification
Selective B1 Agonist
First line in Asthma management
Inhaled B2 agonist
Side Effects of B2 Agonists
Hypokalemia
Muscle Tremors
Tolerance
Tachycardia
Side effect of Clonidine
sedation
depression
rebound HPN
A2 selective Agonist for pregnants
Methyldopa
Side effects Methyldopa
Drug induced lupus
hepatotoxicity
sedation
Give 1 a1 selective agent
Phenyleprhine - decongestants
Centrally Acting Sympathomimetics
Amphtetamine Phtermine Mephenidate PPA Ephedrine
Clinical use of Centrally active sympathomimetics
Anorexients - Appetite suppresants
ADHD
Adrenergic Antagonists classification and examples
Alpha blockers - selective and non selective
Causes irreversible inhibition of a1 and a2
Phenoxybenzamine
Clinical Uses of Phenoxybenzamine
Presurgical management of HPN in pherocromocytoma
Management of Raynaud’s phenomenon
Mgt of Carcinoid syndrome (facial flaring)
causes reversible inhibition of a1 and a2
Phentolamine
Clinical Uses of Beta blockers. give example
Metropolol, Propanolol Uses: 1st line anti HPN Anti arryhtmias Prophylaxis for angina pectoris Management for STABLE CHF glaucoma control sympathetic symptoms of hyperthyroidism
Side effects of Beta Blockers
rebound tachycardia
heart block
decreases exercise tolerance
Contraindicated in Beta blockers
Heart block
Unstable CHF
Bronchial Asthma, COPD
Parasympathetic Muscarinicreceptors location and response
M2 Heart Bradycardia
M1 Vagus nerve Stimulation;add secretion
M3 Glands endothelium Smooth Muscles - vasodilation stiumation and contracion, increase secretion
Direct Acting cholinomimetics
Choline esters - Actch, Metacholine,betanicol
Alkaloids - pilocarpine, muscarine
Clinical uses of Direct Acting Cholinomimetics
Glaucoma
Urinary Retention
Smoking addiction
Used to diagnose Myasthenia Gravis
Edrophonium (Tensilon)
Antidote for Curare poisoning
Neostigmine
Antidote for Atropine Toxicity
Physostigmine
Cholinergic Antagonists example
Atropine
Uses of cholinergic antagonis(atropine)
organophosphate poisoning
symptomatic bradycardia
given with diphenoxylate for prevention of addiction
Used in Parkinsonism
Biperiden
Used to decrease oral secretion during anesthesia
atropine