Neuroembryo Flashcards
<p>primary neurolation</p>
<p>4 weeks</p>
<p>Drug that cuses NTD</p>
<p>valporoic acid</p>
Prosencephalon to
Diencephalon
Telensephalon
Rhombencephalon
Metencephalon
Myelencephalon
Neural groove milestone
18 days
Beginning of myelination
4 weeks
Myelination complete
2 years
Total failure of neurulination
Most aborted spontaneously
Craniorachischis totalis
Failure of anterior neural tube closure
“frog like”
Anencephaly
Defect extends from the level of the lamina terminalis to the foramen magnum
Holoanencephaly
posterior neural tube closure failure
Myeloschisis
Restricted disorder of anterior neural tube closure
frontal lesions are common in SE countries
80% of cases in occipital area
50% - hydrocephalus
Encephalocele
Restricted failure of POSTERIOR neural tube closure
80% lumbar area
Myelomeningocele
Occiputal encephalocele Microcephaly Microphalmia Cleft lip and palate Polydactyly Polycystic kidneys Ambiguous genitalia
Meckel Syndrome
Ambiguous genitalia is seen also in?
Smith lenly Opitz syndrome and
Congenital Adrenal hyperplasia (CAH)
What is Potter’s syndrome?
pulmonary hypertension
potter face
prune belly
What are the organs displaced in Arnold Chiari malformation
Medulla and 4th Ventricle - inferior displacement
Medulla and pons - elongation and thinning
Lower cerebellum - inferior displacement to the foramen magnum
Defects in the foramen magnum. Occiput and cervical vertebrae
When is palatoplasty indicated?
10 weeks
10lbs
10 Hgb
Holoprosencephaly is associated with these chromosomal abnormalities
Trisomy 13-15( patau) Trisomy 18 ( Edwards)
2 types of Neuronal Proliferation
Micrencephaly
Macrencephaly
Macrencephaly is associated with what syndroms?
Tuberous sclerosis
Neurofibromatosis
Sturge Webber syndrome
What are the disorders of Neuronal Migration?
Shcizencephaly
Lissencephaly
Pachygyria
Neuronal Heterotopias
Complete agenesis of a portion of the germinative zone
Pial- ependymal seam
Schizencephaly
Smooth brain or no gyri
Lissencephaly
