neuropharm

Question 1

What does botox do and what is it used for?

Answer 1

Prevent Ach release at alpha motor neuron

Spasticity
Migraine
Dystonia
abnormal eye movement

starts working 48-72 hrs.

Question 2

What is baclophen and what is it used for?

Answer 2

bind to GABA
block Ca from coming to presynaptic terminal -> reduce NT release and hyperpolarization

used for spasticity
SCI
MS

Question 3

Patho of alzheimers?

Answer 3

excess tau/ inadequate clearance.
excess amyloid production

there is brain shrinkage/ loss of cholinergic neuron in frontal cortex
amyloid plaque
neurofibrillary tangles. all from tau.

Question 4

Tx of Alzheimers?

Answer 4

block Ach-ase to make more Ach. present.

via:
AchEI
Glutamade modulator: antagonize NMDA
Behavior treatment: environemtn/mood (SSRI) .agitation.(neuroleptic)

Question 5

L-Dopa/ Carbidopa?

Answer 5

replace Dopamine

inhibit conversion of Ldopa to Dopamine outside of Brain.

Question 6

Antichollinergic

Answer 6

Dec CNS Ach. and Tresore balance of Dopamine and Ach.

Question 7

Different between L-dopa and Dopamine?

Answer 7

Pure dopamine won’t cross BBB but L-dopa will

Question 8

Why is Carbidopa added to L dopa?

Answer 8

Carbidopa inhibities enzymes that break down L-dopa.

Question 9

Side effects of AEDs?

Answer 9

Sedation
Drowsy
Depressed
Dizzy

that can be used to treat bipolar
neuropathic pain
migraine.

AED is antiepilleptic used for seizure.

Question 10

Positive screening test for Intrathecal baclofen?

Answer 10

Drop in spasticity scale

hypotonia w/o resp. difficulty.

Question 11

What are ways to treat parkinson’s?

Answer 11

Dopamine agonist
L-dopa w/ carbidopa
Anticholinergics.