ANS Flashcards
What is function of the ANS?
whats it made up of and what does it innervate?
unconscious control
PSNS/SNS pre/post neuron
smooth/cardiac muscle/glands
PNS NT?
SNS?
Ach
NE
Anatomy in SNS?
thoracolumbar spinal area->synapse in paravertebral chain (Ash b/w pre-post)->post ganglion release NE to adrenergic receptors but Act at sweat gland
pre=short
post=long
Anatomy of PNS
craniosracral-> autonomic ganglia neat target organ via Ach-> post gang release Ach. at muscarinic receptors.
pre=long
post=short
Ach broken down by what?
what is the purpose?
or bind to where?
acetylcholinesterase (enzyme)
so choline can go back into axon to make more Ash.
muscarinic receptors
Where is NE broken down?
what does antidepressants do?
liver
block pump to let NE get back into neuron.
Termination of NE?
- reuptake for storage in neuron
- inactivated by MAO in mitochondria
- bind to adrenergic receptors
- Uptake into extra neural tissue/ metabolized by COMT
What are the different receptors?
Nicotinic
Muscarinic
Adrenergic
Where are nicotinic receptors?
motor end plate
adrenal medulla
autonomic ganglia
Where are muscarinic receptors?
viscera (heart/vascualr/smooth muscle/exocrine)
Where are adrenergic receptors?
a1= smooth muscle/glands
a2=nerve ending smooth muscle
b1= cardiac muscle
b2=lungs
b3: fat
SNS Fx?
a1: vasoConstriction
a2: inhibit SNS
b1: Increase heart stuff and release renin
B2: bronchdilation
gi relax/ inc HR
PNS fx:
rest/digest
only increase is urination
GI mobility
*smooth muscle relax
2 MOA of muscarinic agonist
1: cholinergic agonists directly act at Ach receptor
2: Block AchE (indirect)
ADR of PNS agents?
increased sweating Bronchial constriction Cramps Bradycardia/decrsed CO Incontinent
Indication for muscarinic agonist?
reduce intraocular pressure in glaucoma
Strength SM weekend by MG
increase GI motility
What do anticholinergic drugs do?
what are the ADR?
block muscarinic receptors
dry mouth blurred vision urinary retention tachycardia HTN decreased sweating dementia
Indication for anticholinergic?
parkinsons dilate pupils for exam reduce GI dilate airway treat motion sickness
MOA for adrenergic agonists?
ADR
bind to adrenergic receptor and mimic effect of NE or E.
-increase HR/glucose production/excite CNS
vasoconstriction/reroute blood.
tachycardia/HTN/tremor/pallor/sweat
What are the endogenous catecholamines?
E/NE/Dopamine
Adrenergic Agonist effect at B1/B2/B3?
b1: increase cardiac Fx
b2: relax bronchial/glycogenolysis
b3: lipolysis
indication for adrenergic agonist and when to avoid epi?
anaphylactic shock/homstatic agent/ cardiac arrest
preggo b/c could cause early labor.
Effects of sympathetic NS can be blocked either by
- decreased sympathetic outflow from brain
- blocking postsynaptic receptors.
