ANS

Question 1

What is function of the ANS?

whats it made up of and what does it innervate?

Answer 1

unconscious control

PSNS/SNS pre/post neuron

smooth/cardiac muscle/glands

Question 2

PNS NT?

SNS?

Answer 2

Ach

NE

Question 3

Anatomy in SNS?

Answer 3

thoracolumbar spinal area->synapse in paravertebral chain (Ash b/w pre-post)->post ganglion release NE to adrenergic receptors but Act at sweat gland

pre=short
post=long

Question 4

Anatomy of PNS

Answer 4

craniosracral-> autonomic ganglia neat target organ via Ach-> post gang release Ach. at muscarinic receptors.

pre=long
post=short

Question 5

Ach broken down by what?

what is the purpose?

or bind to where?

Answer 5

acetylcholinesterase (enzyme)

so choline can go back into axon to make more Ash.

muscarinic receptors

Question 6

Where is NE broken down?

what does antidepressants do?

Answer 6

liver

block pump to let NE get back into neuron.

Question 7

Termination of NE?

Answer 7

• reuptake for storage in neuron
• inactivated by MAO in mitochondria
• bind to adrenergic receptors
• Uptake into extra neural tissue/ metabolized by COMT

Question 8

What are the different receptors?

Answer 8

Nicotinic
Muscarinic
Adrenergic

Question 9

Where are nicotinic receptors?

Answer 9

motor end plate
adrenal medulla
autonomic ganglia

Question 10

Where are muscarinic receptors?

Answer 10

viscera (heart/vascualr/smooth muscle/exocrine)

Question 11

Where are adrenergic receptors?

Answer 11

a1= smooth muscle/glands
a2=nerve ending smooth muscle

b1= cardiac muscle
b2=lungs
b3: fat

Question 12

SNS Fx?

Answer 12

a1: vasoConstriction
a2: inhibit SNS
b1: Increase heart stuff and release renin
B2: bronchdilation
gi relax/ inc HR

Question 13

PNS fx:

Answer 13

rest/digest

only increase is urination
GI mobility
*smooth muscle relax

Question 14

2 MOA of muscarinic agonist

Answer 14

1: cholinergic agonists directly act at Ach receptor
2: Block AchE (indirect)

Question 15

ADR of PNS agents?

Answer 15

increased sweating
Bronchial constriction
Cramps
Bradycardia/decrsed CO
Incontinent

Question 16

Indication for muscarinic agonist?

Answer 16

reduce intraocular pressure in glaucoma
Strength SM weekend by MG
increase GI motility

Question 17

What do anticholinergic drugs do?

what are the ADR?

Answer 17

block muscarinic receptors

dry mouth
blurred vision
urinary retention
tachycardia
HTN
decreased sweating
dementia

Question 18

Indication for anticholinergic?

Answer 18

parkinsons
dilate pupils for exam
reduce GI
dilate airway
treat motion sickness

Question 19

MOA for adrenergic agonists?

ADR

Answer 19

bind to adrenergic receptor and mimic effect of NE or E.
-increase HR/glucose production/excite CNS
vasoconstriction/reroute blood.

tachycardia/HTN/tremor/pallor/sweat

Question 20

What are the endogenous catecholamines?

Answer 20

E/NE/Dopamine

Question 21

Adrenergic Agonist effect at B1/B2/B3?

Answer 21

b1: increase cardiac Fx
b2: relax bronchial/glycogenolysis
b3: lipolysis

Question 22

indication for adrenergic agonist and when to avoid epi?

Answer 22

anaphylactic shock/homstatic agent/ cardiac arrest

preggo b/c could cause early labor.

Question 23

Effects of sympathetic NS can be blocked either by

Answer 23

• decreased sympathetic outflow from brain

- blocking postsynaptic receptors.