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Pharm > Chemo > Flashcards

Chemo Flashcards

1
Q

Neoadjuvant therapy

A

Cancer is too large to eliminate initially w surgery so therapy used to shrink followed by radiation/surgery

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2
Q

Adjuvant therapy?

A

Pts Dx with cancer and have surgery to remove it

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3
Q

Side effects of chemo?

A 
Malnourished
Nausea/diarrhea
Alopecia
GI damage
Fatigue/pain
Sterility
Cardiotoxicity
Depression in growth 
Organ toxicity
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4
Q

Why will PT Tx someone with Plant alkaloid (Taxanes)

A

Produces parasthesia

Foot/wrist drop

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5
Q

Tyrosine kinase inhibitors

A

Work inside cell to inhibit tyrosine kinase receptors

Inhibit the signaling system

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6
Q

Mammaliam target of rapamycin?

A

Prevent MTOR from activating signaling pathways involved in angiogenesis and cell growth.

Cancer cant feed itself

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7
Q

Serious side effect of anthracycline ?

A

Cardiotoxicity. Pts get no more than 4 doses

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8
Q

What are mabs?

A

Monoclonal Antibodies?

Flag cancer cells for destruction
Block growth signals and receptors
Prevent angiogenesis

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9
Q

What doe cytokines do?

A

Stimulate T cell growth and help get them revved up

Boost immune system

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10
Q

What do cancer vaccines do?

A

Delay/stop cancer growth. / stop recurrance
Shrink tumor/ eliminate cancer cells

Autologous: From pt-specific materials
Allogenic: Not pt-specific.

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11
Q

Colony Stimulating factors?

A

Regenerate neutrophil recovery following myelosuppressive therapy to minimize extent of nadir and reduce infection

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12
Q

What is neutropenia?

A

Low white blood cell count

Most common side effect of chemo

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13
Q

When should chemo be held?

A

Neutorphil below 500 mm^3 or platelet below 100,000

Do not treat if u are sick

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14
Q

Risk factors for neutropenia

A 
Age
Female
Malnutrition
Open wounds
Comorbidities
Hx of having it
Type of chemo
Dose intensity
Radiation
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15
Q

Signs of infection you should look for in chemo patients?

A

GI: mucositis/diarrhea
Respiratory Tract: Cough/dyspnea/abnormal breath
Urinary: Dysuria/frequency/urgent/color

Redness tender/warm

Flu-like/fever/chills/fatigue

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16
Q

Most reliable sign of infection for patients with neutropenia?

A

> 38 D celcius fever.

Septic shock from neutropenia has high mortality rate.

17
Q

Risk factors for thrombocytopenia?

A

It is low platelet count

Myelosuppresive chemo
Radiation
Bone marrow involvment
DIC
Fever
Nutrition deficiency
18
Q

Clinical signs of thrombocytopenia?

A 
Ptechiae/bruising
Overt bleeding
Enlarged liver/spleen
Blood in stool/urine
Headache
Hypotension
Tachy
Prolonged menstruation
19
Q

What is a vesicant injury?

A

Cause severe muscle and tissue damage in leakage outside vein.

Pharm (14 decks)

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