Neurons Flashcards

1
Q

neuron types (3)

A
  • sensory neuron
  • interneuron
  • motor neuron
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2
Q

neuron structure

A

structural variation:

- can be very long or short

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3
Q

neuron components (3)

A
  • cell body
  • dendrites
  • axon
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4
Q

neuron cell body

A
  • maintains the normal cell functions of the neuron
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5
Q

neuron dendrites

A
  • receive incoming information
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6
Q

neuron axons

A
  • communicate electrical signals across long distances
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7
Q

where do electrical signals occur in neurons

A
  • dendrites, cell body, axon, and synapse
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8
Q

glial cells (2)

A
  • support and surround neurons to maintain them

- required for proper neuron functioning

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9
Q

neural reflex pathways (2)

A
  • simplest neural pathways

- don’t involve brain or consciousness

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10
Q

sensory neuron

A
  • afferent neurons that send signals toward the CNS
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11
Q

motor neuron

A
  • efferent neurons that send signals away from the CNS
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12
Q

sensory receptors and membrane potential (2)

A
  • incoming stimulus causes change in conformation of receptor protein
  • causes a signal within the cell that ultimately changes membrane potential
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13
Q

what determines signal intensity in neurons (2)

A
  • frequency of action potentials; # of action potentials/time
  • more pressure to neuron when there is higher intensity
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14
Q

graded potentials (3)

A
  • occurs in dendrites and cell body
  • only travel short distances
  • vary in magnitude and sign
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15
Q

action potentials (3)

A
  • occur in axons
  • all or none (always look the same within the cell)
  • can be regenerated and conducted along long distances
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16
Q

synaptic potentials (2)

A
  • action potentials arriving at synapse

- cause the release of neurotransmitters

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17
Q

what causes electrical signals in neurons

A
  • graded, action, and synaptic potentials all result in changes in the membrane potential of the cell
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18
Q

depolarization (2)

A
  • becoming more positive

- smaller difference between inside and outside of cell

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19
Q

hyperpolarization (2)

A
  • becoming more negative

- bigger difference between inside and outside of cell

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20
Q

membrane potential (3)

A
  • voltage differences across the membrane
  • always reported as charge inside relative to outside
  • in both animals and plants, inside of the cell is more negative than outside at rest
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21
Q

Nernst equation

A
  • allows you to calculate the equilibrium potential of any ion
22
Q

how do we predict the direction of ion movement

A
  • compare the equilibrium potential of that ion with the membrane potential of the cell
23
Q

permeability importance (2)

A
  • final membrane potential is a weighted average of the equilibrium potentials of the ions and permeability provides the weighting factor
  • increased permeability for an ion will increase its weight/importance
24
Q

why do we only consider Na+, K+ and Cl- in the Goldman equation

A
  • permeability of the membrane to other ions is extremely low under resting conditions
25
Q

permeability and equations

A
  • when permeability to one ion is much higher than to other ions, the Nernst and Goldman equations are the same
26
Q

what is the function of changes in membrane potential (2)

A
  • can act as signals within cells
  • occur in many cell types in both animals and plants; animals have nerves and tissues that are specialized for electrical signalling
27
Q

what causes changes in membrane potential

A
  • change in the membrane permeability (channels opening and closing)
28
Q

how is permeability regulated

A
  • gated ion channels
29
Q

how do gated ion channels work

A
  • open and close in response to incoming signals
30
Q

what causes a graded potential

A
  • binding of neurotransmitter to a receptor
31
Q

what sets the size of a graded potential

A
  • depends on amount of neurotransmitter
  • more neurotransmitter = more channel opening/closing = larger change in permeability = larger change in membrane potential
32
Q

why can graded potentials only travel short distances

A
  • intracellular resistance and leakage of ions across the membrane cause the signal to degrade with distance; gets weaker as it travels
33
Q

how are action potentials triggered (3)

A
  • graded potentials in the dendrites and cell body alter membrane potential in the axon hillock (trigger zone)
  • membrane potential must exceed the threshold potential
  • results in action potentials in the axon
34
Q

threshold potential

A
  • 55 mV
35
Q

resting potential

A
  • 70 mv
36
Q

spatial summation (3)

A
  • graded potentials originating at different locations can influence the net change in membrane potential, allowing the neuron to reach threshold
  • many positive close together grade potentials can cause the neuron to reach threshold
  • positive and negative graded potentials can cancel each other out
37
Q

changes in permeability that occur during the action potential

A
  • large increase in Na+ permeability
  • followed by increase in K+ permeability
  • occurs due to the opening of voltage-gated channels
38
Q

when do Na+ voltage-gated channels open

A
  • when the membrane is depolarized
39
Q

positive feedback of Na” voltage-gated channels (3)

A
  • positive feedback causes rapid depolarization
  • Na+ channel activated gates open -> Na+ enters the cell -> more depolarization -> more gates open
  • feedback loops closes after a certain amount of channels close
40
Q

how does Na+ channel density affect neuron function (2)

A
  • higher density of voltage-grated Na+ channels creates lower threshold required to trigger an action potential
  • increases excitability
41
Q

how do neurons return to resting MP

A
  • inactivation gate on the VG Na+ channel
  • VG K+ channels are not required, but are helpful and are responsible for the hyperpolarization phase of the action potential
42
Q

absolute refractory period (2)

A
  • inactivation gate closed

- no new action potential is possible

43
Q

relative refractory period (3)

A
  • inactivation gate open
  • new action potential possible, but less likely because neuron is hyperpolarized
  • only occurs in neurons with VG-K+ channels
44
Q

what is the purpose of the refractory periods

A
  • makes it less likely for many action potentials to occur consecutively
45
Q

action potential propogation (2)

A
  • action potentials spread as a wave of depolarization; an electronic current flow
  • this triggers actions potentials to be re-generated in nearby regions of the membrane
46
Q

if a neuron is depolarized in the middle of the axon, which direction would the resulting action potential travel? (2)

A
  • in both directions because the inactivation gates are open on both sides
  • normally, it will travel toward the synapse due to inactivation gates closing behind it
47
Q

myelin (4)

A
  • formed by Scwhann cells wrapped around axons
  • insulates the axon
  • allows charge to spread further down the axon without degrading (decreasing below threshold) so that fewer action potentials are needed to send signals
  • causes saltatory conduction
48
Q

saltatory conduction

A
  • apparent “leaping” of action potential from node to node
49
Q

synapses (2)

A
  • can be chemical or electrical

- neurotransmitters are rapidly removed from the synapse

50
Q

chemical synapses

A
  • convert electrical signals to chemical signals

- neurotransmitters are released into the synapse when VG Ca+ channels open