neuronal Nicotinic agonists

Question 1

What does nicotine do?

Answer 1

This acts both centrally and peripherally on the Ach receptors.

SC: Nicotine toxicity results in initial excitation, but the receptors will become desensitized and then you will see a depressed state.

Question 2

What does Acetylcholine do?

Answer 2

Ach is an endogenous transmitter that acts on nicotinic and muscarinic receptors.

SC: Due to the overlap on the PNS and SNS, it is not used therapeutically