Cholinergic Agents: Muscarinic Antagonists Flashcards
What is the muscarinic antagonist atropine used for?
Atropine is a muscarinic antagonist that crosses the BBB and can cause CNS effects. It is often used to reverse adverse effects of agonists, such as mushrooms or alkaloid plants.
special considerations: low doses of atropine cause bradycardia while higher doses cause tachycardia. This is because atropine will block a receptor important for inhibition of Ach release- therefore more Ach will be released initially and cause parasympathetic response
What does the muscarinic antagonist glycopyrrolate do?
Glycopyrrolate lasts longer than atropine but doesn’t cross the BBB. General effects are relaxation of non-vascular smooth muscle: inhibit GI motility, inibit gland secretion, brady or tachycardia depending on dose
