Neuromuscular junction Flashcards
What is conductance?
How easily the ions move through an ion channel (opposite of resistance)
What are the units of charge?
Colombs
What is ohm’s law?
V= IR
What are the different (both extracellular and intracellular) ion distributions in the body?
Na
K
Ca
Cl
What is the equilibirum potential?
When the electric and concentration gradient (electrochemical gradient) balance
What does the nernst equation calculate?
Equilibrium potential
What is the nernst equation?
When calculating E(A+B) what do you do?
E(A+B)= E(A)+E(B)
= the sum of the two equilibrium potentials
What feature of postynaptic membranes increases the surface area?
Pits
What is the end plate potential?
Depolarisation of the endplate
What are the two different presynaptic drug targets?
- Transmitter release
- Transmitter reuptake
What is the result of too much vesicle release at the neuromuscular junction?
Spacticity
What are the two different postsynaptic drug targets?
Non-depolarising blockers
Depolarising blockers
What type of antagonists are non depolarising blockers?
Competitive
Give three examples of non depolarising blockers:
Alpha bungarotoxin
Tubocurarine (curare)
Gallamine
