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Jason's MD2 Intersession 3 > Neuromuscular Diseases > Flashcards

Neuromuscular Diseases Flashcards

1
Q

distribution of the neuromuscular disorders?

A

focal

generalised

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2
Q

proximal weakness usually indicates?

A

myopathy

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3
Q

distal weakness typically from what?

A

neuropathy

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4
Q

what causes diplopia and ptosis in neuromuscular disorders?

A

Myasthenia
ocular nerve palsy
thyroid eye disease
NOT motor neuron disease

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5
Q

dysphagia in which neuromuscular disorders?

A

MGravis

MND

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6
Q

what neuromuscular disorders are common for fasciculations?

A

anterior horn cell disease

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7
Q

which neuromuscular disorders have normal reflexes?

A

MGravis

myopathy

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8
Q

any sensory loss in Motor Neuron Disease?

A

Nope

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9
Q

are ocular muscles involved in MND?

A

nope

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10
Q

treatment for MND?

A

Riluzole (glutamate antagonist)

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11
Q

what is primary lateral sclerosis?

A

pure upper motor neuron

no LMN signs, not as bad as ALS

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12
Q

key for myasthenia gravis?

A

fatiguable weakness

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13
Q

how are reflexes and sensation in myasthenia gravis?

A

normal

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14
Q

how to test dx myasthenia gravis?

A

tensilon test

short acting acetylcholinesterase antagonist

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15
Q

blood test for myasthenia gravis?

A

autoantibodies -Ach receptor, MuSK

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16
Q

when would you get thymoma?

A

myasthenia gravis

17
Q

tensilon test use what drug?

A

edrophonium

18
Q

Rx of myasthenia gravis?

A 
steroids/azathiprine
long acetylcholinesterase antagonists
plasma exchange
thymectomy
IV immunoglobulin
19
Q

common causes of focal neuropathies?

A

compressive
infection
inflammatory

20
Q

monomneuritis multiplex usually cause?

A

usually ischaemic
DMII, vasculitis

rarely infective: AIDS, CMV, sarcoid, leprosy

21
Q

2 kinds of acute polyneuropathies

A

demyelinating: guillan-barre, tumour, AIDS seroconversion

More common: axonal: thiamine, prphyria, vasculitis, glue sniffers

22
Q

Chronic polyneuropathies most common causes?

A

Diabetes
thiamine def.
toxins
hypothyroid

23
Q

How to assess neuromuscular disorders?

A

CK
electrophysiology
family history and genetics tests
muscle biopsy

24
Q

3 kinds of neuromuscular disorders?

A

peripheral nervous system
neuromuscular junction
muscle

Jason's MD2 Intersession 3 (11 decks)

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