Allergies Flashcards
allergy investigations?
RAST (serologic assays) or skin test
Challenge testing
IgE in vitro assays, while one use these days?
CAP-FEIA
Kinda of ELISA
in vitro assays advantages?
standardized
GPs can prescribe
more quantitative
gold standard for allergy testing?
challenge tests
what drugs can influence post natal?
penicillins
paracetomol
mechanism of IgE B-cell production
Th2 released IL4 tend to shift B-cells to make IgE
what’s the only good treatment for allergies?
immunotherapy subcut injections
what is contraindicated to allergy immunotherapy?
betablockade
future immunotherapy?
sublingual delivery system
how to give immunotherapy injections?
always wait 30 minutes after
give antihistamine prior
anaphylaxis presentation?
cardiovascular
respiratory, upper and lower
rash
atypical anaphylaxis
older and young: GIT involvement without rash
angioedema is what?
deep tissue swelling, esp in larynx
angioedema need allergen to contact mouth to get larynx swelling?
Nope. systemic reaction
who are most at risk of dying of anaphylaxis food allergy?
12-24 year olds
insect venom anaphylaxis, which creatures?
jumper ants
honey bee
european wasps
dose for adrenaline for adrenaline
- 5mg of adrenaline
children: 0.01mg/kg up to 0.5mg
mild allergic reactions
oral anti-histamines
when give adrenaline? after first dose?
every 20 minutes : 0.5mg for adults
up to 3 doses
treatment protocol for allergic rhinitis
nasal corticosteroids
antihistamines
immunotherapy
thunderstorm asthma is what?
thuderstorms bring up pollens, they burst and allergens are rained down onto allergic ppl.
what is an allergen?
protein that elicits an IgE response
