Neuromuscluar blockades

Question 1

ED95 and intubating dose of doxacurium.

Answer 1

ED95: 0.03

intubating dose: 0.05-0.08 mg/kg

Question 2

onset and duration of doxacurium.

Answer 2

onset: 4-5 minutes
duration: 60-90 minutes

Question 3

ED95 and intubating dose of pipecuronium

Answer 3

ED95: 0.05 mg/kg

intubating dose: 0.085 mg/kg

Question 4

onset and duration of pipecuronium.

Answer 4

onset: 3-5 minutes
duration: 60-90 minutes

Question 5

ED95 and intubating dose of pancuronium

Answer 5

ED95: 0.07 mg/kg

intubating dose: 0.1 mg/kg

Question 6

onset and duration of pancuronium.

Answer 6

onset: 3-5 minutes
duration: 60-90 minutes

Question 7

ED95, intubating dose, maintenance dose, and infusion rate of vecuronium.

Answer 7

ED95: 0.05 mg/kg
intubation dose: 0.1 mg/kg
maintenance dose: 0.015 mg/kg
infusion rate: 1 mcg/kg/min

Question 8

onset and duration of vecuronium.

Answer 8

onset: 2.3 minutes
duration: 45-60 minutes

Question 9

ED95, intubating dose, maintenance dose, and infusion rate of mivacurium

Answer 9

ED95: 0.08 mg/kg
intubation dose: 0.15-0.2 mg/kg
maintenance dose: 0.1 mg/kg
infusion rate: initial 9-10 mcg/kg/min, then 6-7 mcg/kg/min

Question 10

onset and duration of mivacurium

Answer 10

onset: 1.5-3 minutes
duration: 12-20 minutes

Question 11

ED95, intubating dose, maintenance dose, and infusion rate of cisatracurium

Answer 11

ED95: 0.05 mg/kg
intubating dose: 0.1 mg/kg
maintenance dose: 0.03 mg/kg
infusion rate: 1-2 mcg/kg/min

Question 12

onset and duration of cisatracurium

Answer 12

onset: 2-3 minutes
duration: 20-35 minutes

Question 13

ED95, intubating dose, maintenance dose, and infusion rate of atracurium

Answer 13

ED95: 0.2 mg/kg
intubating dose: 0.5 mg/kg
maintenance dose: 0.07 mg/kg
infusion rate: 6-8 mcg/kg/min

Question 14

onset and duration of atracurium

Answer 14

onset: 2-3 minutes
duration: 20-35 minutes

Question 15

ED95, intubating dose, maintenance dose, and infusion rate of rocuronium

Answer 15

ED95: 0.3 mg/kg
intubating dose: 0.6 mg/kg
maintenance dose: 0.1 mg/kg
infusion rate: 10-12 mcg/kg/min

Question 16

onset and duration of rocuronium

Answer 16

onset: 1-2 minutes
duration: 20-35 minutes

Question 17

ED95, intubating dose, and infusion of SCh

Answer 17

ED95: 0.3 mg/kg
intubating dose: 1-1.5 mg/kg IV 4-5 mg/kg IM
infusion: 1gm/500cc

Question 18

onset and duration of SCh

Answer 18

onset: 45-90 seconds
duration: 5-10 minutes

Question 19

What is the defasciculation dose or “precurarization” dose of d-Tubocrarine (Curare)?

Answer 19

3 mg

Question 20

Which drugs are mostly eliminated by the kidneys (longer)?

Answer 20

Pancuronium: 80%
Doxacurium mostly renal
Pipecuronium: all unchanged in urine NO LIVER

Question 21

What drugs are prolonged with renal failure?

Answer 21

Pancuronium
Doxacurium 
Pipecuronium 
Vecuronium 
Rocuronium 
Laudanosine 
Mivacurium (if causes plasma cholinesterase activity to decrease)

Question 22

What drugs cause histamine release?

Answer 22

Curare
Atracurium
Mivacurium
*vecuronium inhibits the breakdown of histamine
*atracurium and mivacurium histamine release cause hypotension and tachycardia
-prophylaxis: low doses, slow admin, pretreat with H1 and H2 blockers (Benadryl and Pepcid)