benzo, flumazenil, naloxone, doxapram dosages

Question 1

dose of midazolam for pediatric premedication

Answer 1

0. 3-0.5 mg/kg po (30 min)

* max dose 10 mg (teenagers)

Question 2

dose of midazolam for sedation

Answer 2

1-2.5 mg IV

*flexible depending on need

Question 3

dose of midazolam for induction

Answer 3

0. 1-0.2 mg/kg IV

* *remember apnea occurs with dose >0.15 mg/kg IV

Question 4

what is the dose of diazepam?

Answer 4

10-15 mg po (adult)

Question 5

what is the dose of lorazepam?

Answer 5

50 mcg/kg (up to 4mg)

Question 6

what is the dose of flumazenil?

Answer 6

initial: 0.2 mg IV (8-15 mcg/kg)
additional: 0.1 mg IV at 60 sec intervals (max dose 1 mg; ceiling effect)

Question 7

what is the dose of flumazenil for decreased sedation?

Answer 7

0.3-0.6 mg

Question 8

what is the dose of flumazenil to abolish the benzo effect?

Answer 8

0.5-1 mg

Question 9

what is the dose of naloxone?

Answer 9

0. 5-1 mcg/kg (35-70 mcg) every 3-5 min

* dilute 0.4 mg/ml to 40 mcg/ml (0.04 mg/ml)

Question 10

what is the dose of naloxone to reverse ventilatory depression d/t maternal opioids in neonates?

Answer 10

10 mcg/kg every 2 min

Question 11

what is the dose of doxapram?

Answer 11

0.5-1 mg/kg (max 4 mg/kg)