Neuromorphology Flashcards

1
Q

at how many days does neurulation occur?

A

begins at 18 days

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2
Q

describe neurulation

A

thickeming of ectoderm that results in tall columnar cells in the neural plate on the dorsal midline of embyro

occurs immediately dorsal to notochord and results in the neural groove

neural groove becomes deeper d/t increased cell growth. eventually the dorsal neural crests meet and form a tube. this process occurs first in cervical region and progresses up and done

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3
Q

neural crest cells

A

neural crest cells are derived from the crests of the neural groove and the floorplate of the groove

become the sensory ganglia (such as dorsal root ganglia)

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4
Q

where does the ventricle system of the brain come from

A

the middle of the neural tube

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5
Q

how many cell layers thick is the wall of the neural tube?

A

1 cell

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6
Q

how does the neural tube close

A

closes both caudally and rostrally, leading down to anterior and posterior neuropore

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7
Q

what are the last parts of the neural tube to close?

A

anterior and posterior neuropore

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8
Q

anterior neuropore fails to close

A

anencephaly- death

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9
Q

posterior neuropore fails to close

A

spina bifida

spina bifida occulta- minor defect where lamina of vertebrae don’t fully fuse

meningocele- meninges bulge out of palce

meningomyelocele- spinal cord and meneinges are bulging out of canal. associated w/ damage to lower spinal cord and nerve roots

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10
Q

how cap spina bifida be prevented?

A

folic acid supplementation before pregnancy

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11
Q

cevical and cephalic flexure

A

after anterior neural pore closes, tube elongates faster than embyro can keep up. this causes a bends in the neural tube, called the cervical and cephalic flexures

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12
Q

how do the vesicles form?

A

after the anterior neural pore closes, the tube elongates faster than embryo can keep up. creates bulges in the transverse plans that become vessicles

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13
Q

rhombencephalic vesicle

A

at level of brain stem

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14
Q

mesencephalic vesicle

A

at level of midbrain

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15
Q

prosencephalic vesicle

A

most rostral vesicle. eventually differentiates into diencephalic vesicle and two telencephalic vesicles on either side of it

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16
Q

pontine flexure

A

an anterior flexure that forms in the rhombencephalic vesicle, which separates it into the mylenephalon caudally and metencephalon rostrally

17
Q

lateral ventricles develop from?

A

telecephalic vesicles

18
Q

third ventricle develops from?

A

diecephalic vesicle

19
Q

what forms the cerebral aqueduct

A

mesencephalic vesicle

20
Q

fourth ventricle develops from what?

A

metencephalic and myelencephalic vesicles

21
Q

neural crest cells become what

A

dorsal root ganglia and all sensory nerves
ganglia of cranial nerves
autonomic ganglia- gut
adrenal medulla
schwann cells
leptomeninges
bone and connective tissues of face and skull

22
Q

what is important for initiation of the neural tube

A

bone morphogenetic protein (BMP) is secreted by ectoderm and must be inhibited by noggin and chordin, which bind to BMP and inhibt it

23
Q

where do noggin and chordin come from/

24
Q

what does sonic hedgehog do?

A

secreted from notochord, (and eventually floorplate) causes ventral differentiation

25
what do TGF betas do?
secreted by neural crest cells secrete TGF beta like BMP to cause dorsal spinal differentiation. they are no longer inhibited by noggin and chordin b/c the neural tube is much bigger and thus the concentration are much smaller
26
why is cholesterol important for SHH?
SHH is released inactive SHH is autoproteolytic, and cholesterol binds to N-terminus which is required for proper diffusion and activity statins inhibit this and cannot be taken during pregnancy
27
basal/alar plate
basal- contains motor neurons alar plate- becomes dorsal horn involved in sensory processing in the brainstem, motor neurons are medial and sensory are lateral
28
why is retonic acid important
important for determining to rostral and caudal. diffuses from brainstem and activates Hox genes, close to retnoic acid = caudal certain acne drugs have retonic acid analogues, but cannot be taken during pregnancy
29
what do the cells in the wall of the neural tube become?
macroglia- cells of the CNS
30
what are notch 1 and numb
cell surface molecules- notch 1 occurs closer to pia and numb occurs basally notch 1 signals cells to stop dividing, migrate away into mantle zone and mature
31
notch v delta
notch and delta are both cell membrane proteins that interact w/ each other. when one cell upregulates notch, it down regulates notch on adjacent cells and upregulates delta. delta does the reverse. this creates a good ratio of glia and neurons. glia are high notch cells
32
radial glial cells
they radiate from ventricle surface outward in waves, using surface markers on the glia
33
cajal retzius cells
found in layer 1, secrete reelin which is important for normal migration
34
what factors influence the differentiation of the neural crest cells
leukocyte inhibiting factor- sensory neuron FGF2- sympathetic cell stem cell factor- melanocyte glucocorticoids- chromaffin cell