Neurology Pharmacology Flashcards
What is the use of neuromuscular blocking drugs?
Used for muscle paralysis in surgery or mechanical ventilation
Selective for motor nicotinic receptor
What are the two classes of NMB drugs?
Depolarizing and Nondepolarizing
What is the mechanism of dantrolene?
Prevents the release of Ca2+ from the sarcoplasmic reticulum of skeletal muscle
Clinical use of dantrolene
Used in the treatment of malignant hyperthermia, a rare but life-threatening side effect of inhalation anesthetics and succinylcholine
Also used to treat neuroleptic malignant syndrome
What 5 majore drugs are used to treat Parkinson’s?
BALSA
Bromocriptine
Amantadine
Levodopa (with carbidopa)
Selegiline (and COMT inhibitors)
Antimuscarinics
What is the strategy of bromocriptine in treating Parkinson’s?
Dopamine agonist
What is hte strategy of amantadine in treating Parkinson’s?
Increase dopamine
What is the toxicity of amantadine?
Tremor
Whatis the strategy of L-dop/carbidopa in treating Parkinson’s?
Increase dopamine
What is the strategy of selegiline in treating Parkinson’s?
Prevent dopamine breakdown
What enzyme does selegiline inhibit to prevent dopamine breakdown?
Selective MAO type B inhibitor
What is the strategy of entacapone and tolcapone in treating Parkinson’s?
Prevent dopamine breakdown
What enzyme does entacapone and tolcapone inhibit to prevent dopamine breakdown?
COMT
What specific antimuscarinic is used to treat Parkinson’s?
Benztropine
What is the strategy of benztropine in treating Parkinson’s?
Curb excess cholinergic activity
Why is L-dopa used rather than dopamine to increase level of dopamine in brain?
Unlike dopamine, L-dopa can cross the BBB and is converted by dopa carboxylate in the CNS to dopamine