Neurology Flashcards
Ischemic strokes < ____ hours old are usually not visible on CT
6
Riluzole
treatment modestly increases survival in ALS by decreasing presynaptic glutamate release
Facial nerve palsy is seen as a complication in what diseases?
AIDS, Lyme, Sarcoid, Tumors, Diabetes
Single greatest risk factor for stroke?
HTN
Nerve root: achilles?
S1
Nerve root: patella
L3,4
Nerve root: biceps
C5
Nerve root: triceps
C7
Name artery: contralateral paresis, sensory loss in leg, cognitive and personality change
ACA
Name artery: homonymous hemianopia, vertigo
PCA
Name artery: pure motor, pure sensory, ataxic hemiparesis, dysarthria
Lacunar
contralateral paresis, sensory loss in face and arm, gaze to side of lesion, neglect if non-dom hemisphere, aphasia if dom hemisphere
MCA
Target INR when someone has a prosthetic valve?
2.5-3.5
Etiologies of SAH?
ruptured berry aneurysm (saccular aneurysm), AVM, trauma to circle of willis
Rapid onset of “worst HA of my life” with photophobia and neck stiffness?
SAH
If CT is negative and you have suspicion of SAH what should you do?
LP (RBCs, xanthochromia)
Once SAH has been confirmed, next test?
Four vessel angiography
Conditions associated with berry aneurysm that make SAH more likely diagnosis?
Marfan, aortic coarc, ADPKD, ehlers danlos, sickle-cell anemia, smoking, atherosclerosis, htn
Treatment for SAH?
- -neurosurg for definitive
- prevent rebleed (BP <150)
- revent vasospasm/ischemic stroke (CCBs- nimodipine)
- decrease ICP
- treat hydrocephalus with lumbar drain, serial LPs, ventriculoperitoneal shunt
Major cause of delayed morbidity/mortality in SAH?
vasospasm- ischemic stroke
Early and late signs and symptoms of intracerebral hemorrhage are?
early: focal motor, sensory deficits that worsen as hematoma expands
late: increased ICP (vomit, HA, brady, reduced altertness)
Suspect herniation if patient develops _____
Cushing’s triad: hypertension, brady, irregular respiration)
common etiology for septic thrombosis of cavernous sinus?
central face skin infection, orbit infection, sinus infection.
blown pupil suggests impending ____
ipsilateral brainstem compression
Rupture of bridging veins
subdural
more common hematoma in elderly and alcoholics
subdural
immediate loss of consciousness, followed by lucid interval and then subsequent loss of consciosness (changes over minutes/hours)
epidural
most common bug causing cavernous sinus infection
staph aureus
Abortive therapy for migraines
triptans (after NSAIDS)
Prophylactic migraine therapy
anticonvulsant (gabapentin, topiramate, TCAs, B-block, CCB)
First episode of cluster HA require?
MRI, carotid artery ultrasound (to exclude brain lesion or disorders associated with horner like CA dissection or cavernous sinus infection)
Prophylactic therapy for cluster HA?
verapamil
in patients > 50 with new HA what should you do?
ESR to rule out GSA
patient presents with uncontrollable twitching of his thumb and is fully aware of symptoms. what kind of seizure?
simple, partial seizure
patient presents with lip smacking and impaired level of consciousness followed by confusion? type of seizure?
complex partial
simple seizure means
no impaired LOC
EEG normal during concerning seziure think?
pseudoseizure
first line anticonvulsant in children?
phenobarbital
2nd line for absence seizure
valproic acid
what should you give a patient who has been seizing > 5 mins to treat potential etiologies?
thiamine, glucose, naloxone
Treatment for status epi?
IV benzo at 5 mins. Another IV benzo 5-10 mins after if needed. If 20 minutes go by, give fosphenytoin.
BPPV
otolith leads to disturbance in semicircular canals.
patients with transient episodic vertigo lasting < 1 min and nystagmus triggered by changes in head position?
BPPV
vertigo and vomiting for 1 week after recovering from viral infection?
vestibular neuritis
epley maneuver can be used to resolve?
BPPV
What may present with similar symptoms to labrynthitis?
anterior inferior cerebellar artery stroke
Treatment for optic neuritis?
IV steroids
how can you distinguish ALS from cervical spondylosis?
bulbar involvement suggests pathology above foreman magnum-> ALS
periodic sharp wave complexes on EEG?
creutzfeld-jakob
clumps of alpha synuclein proteins
lewy body
cerebral atrophy of caudate/putamen, altered behavior, dementia and random movements?
huntington (CAG repeats on chrom 4)
how can you differentiate gait in NPH from gait in parkinson’s?
preservation of arm swing i n NPH
Parkinson tetrad
resting tremor (decreases with voluntary movement)
rigidity
bradykinesia
stooped posture (instability)
etiology of parkinson disease.
DA deficiency in substantia nigra, Ach excess
etiology of Alz
Ach and NE deficient
most common primary CNS tumors in adults
glioblastoma multiforme
meningioma
rhabdo of heart esp in apex of LV affects 50% of patients with?
tuberous sclerosis
sebaceous adenomas in a butterfly distribution?
tuberous sclerosis
Infantile spasms may be an early sign of
tuberous sclerosis
left superior MCA stroke in posterior inferior frontal cortex may cause?
broca aphasia
left posterior superior lobe. due to inferior MCA stroke?
wernicke aphasia
encephalopathy, ophthalmoplegia, ataxia
wernicke encephalopathy
anterograde and retrograde amnesia, horizontal nystagmus, confabulations
korsakoffs (irreversible)
open angle glaucoma occurs _____ while closed angle glaucoma occurs _____
bilaterally.
unilaterally
gradual loss of peripheral vision?
open angle glaucoma
painless loss of central vision with distortion of straight lines?
macular degeneration