Parkinson Meds

Question 1

Anticholinergic meds

Answer 1

benztropine and trihexphenidyl

Question 2

anticholinergic meds effect?

Answer 2

block tremor and rigidity.

watch for dry mouth, worsening prostate hypertrophy and constipation. Relatively Contraindicated in patients >60

Question 3

Amantadine

Answer 3

possible MOA is increasing release of DA in substantia nigra. Use for tremor and rigidity in patients >60 intolerant to anti-cholinergics

Question 4

DA agonists

Answer 4

pramipexole and ropinirole

Question 5

best initial therapy for severe Parkinsonism?

Answer 5

pramipexole and ropinirole

Question 6

most effective med in parkinosnism?

Answer 6

Levodopa/Carbidopa

Question 7

Med associated with “on/off” resulting in bradykinesia with insufficient DA and dyskinesia with too much DA

Answer 7

levodopa/carbidopa

Question 8

Medications you add to levodopa/carbidopa to even out DA level or when response to therapy is inadequate

Answer 8

tolcapone and entacapone

COMT inhibitors

Question 9

MAO inhibitors

Answer 9

rasagiline and delegiline block metabolism of DA

Question 10

What class of drugs are proven to slow progression of PD?

Answer 10

MAO Inhibitors

Question 11

Pramipexole and ropinirole can also be used to treat?

Answer 11

restless leg syndrome

Question 12

treatment for dyskinesia in huntington’s disease?

Answer 12

tetrabenazine

Question 13

In multiple sclerosis, Natalizumab treatment is associated with development of?

Answer 13

progressive multifocal leukoencephalopathy

Question 14

What drug treats spasticity in ALS?

Answer 14

Baclofen

Question 15

Drug that slows progression of disease in ALS?

Answer 15

Riluzole

Question 16

best initial therapy for facial nerve palsy? additional therpy if needed?

Answer 16

prednisone.

acyclovir

Question 17

most common complication of cranial nerve palsy?

Answer 17

corneal ulceration because of difficulty closing the eye.