Neurology Flashcards

1
Q

What are the main types of primary headaches in children?

A
  • Tension-type
  • Migraine with/without aura
  • Cluster headaches
  • Trigeminal neuralgia
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2
Q

What are secondary headaches attributed to in children?

A
  • Raised ICP - due SOL/hydrocephalus/idiopathic intracranial hypertension etc.
  • Infection - meningitis, encephalitis
  • Acute sinusitis
  • Substance misuse/withdrawal
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3
Q

If a child was presenting with a headache, what would you want to do as part of the examination?

A
  • Growth parameters, OFC, BP
  • Sinuses, teeth, visual acuity
  • Fundoscopy
  • Visual fields (craniopharyngioma)
  • Cranial bruit
  • Focal neurological signs
  • Cognitive and emotional status
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4
Q

What features might point towards a migraine being the cause of a headache in a child?

A
  • Associated abdominal pain, nausea, vomiting
  • Focal symptoms/ signs before, during, after attack: Visual disturbance, paresthesia, weakness
  • ‘Pallor’
  • Aggravated by bright light/ noise
  • Relation to fatigue/ stress
  • Helped by sleep/ rest/ dark, quiet room
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5
Q

What is the difference between tension headache pain and migraine pain in terms of distribution of pain?

A

Migraine is hemicranial, whereas tension is diffuse/symmetrical

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6
Q

What is the difference between tension headache pain and migraine pain in terms of quality of pain?

A

Migaine is throbbing/pulsatile, whereas tension is like a tight band round the head, and is a constant ache

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7
Q

What features might point towards a medication overuse headache?

A
  • Headache is back before allowed to use another dose
  • Paracetamol/ NSAIDs
  • Particular problem with compound analgesics eg. Cocodamol
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8
Q

What are red flag symptoms of a headache in a child?

A
  • Worse on lying down
  • Wakes up with headache
  • Associated confusion
  • Persistent/morning vomiting
  • Recent change in personality
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9
Q

What are red flag clinical signs in headaches in children?

A
  • Growth failure
  • Visual field defect
  • Squint
  • Cranial nerve abnormality
  • Torticollis
  • Obnormal coordination
  • Gait abnormalities
  • Papilloedema
  • Bradycardia
  • Cranial bruits
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10
Q

When would you consider neuroimaging in a child with headaches?

A
  • Features of cerebellar dysfunction
  • Features of raised intracranial pressure
  • New focal neurological deficit eg. new squint
  • Seizures, esp focal
  • Personality change
  • Unexplained deterioration of school work
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11
Q

How would you manage migraines in children?

A
  • Acute - NSAIDs, Triptans
  • Preventative - Pizotifen, propranalol, amytriptilline, topiramate, valproate
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12
Q

How would you manage tension type headaches in children?

A
  • Aim at reassurance: no sinister cause
  • MDT management - Attention to underlying chronic physical, psychological or emotional problems
  • Acute attacks: simple analgesia
  • Prevention: Amitryptiline
  • Discourage analgesics in chronic TTH
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13
Q

What is the definition of an epileptic seizure?

A

An abnormal excessive hyper synchronous discharge from a group of (cortical) neurons

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14
Q

What is the definition of epilepsy?

A

A tendency to recurrent, unprovoked (spontaneous) epileptic seizures

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15
Q

What are non-epileptic type seizures which can occur in children?

A
  • Acute symptomatic seizures: due to acute insults eg. Hypoxia-ischaemia, hypoglycemia, infection, trauma
  • Reflex anoxic seizure: common in toddlers
  • Syncope
  • Parasomnias eg. night terrors
  • Behavioural stereotypies
  • Psychogenic seizures (NEAD)
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16
Q

What is a febrile convulsion?

A

An event occurring in infancy/ childhood, usually between 3 months and 5 years of age, associated with fever but without evidence of intracranial infection or defined cause for the seizure. Seizures are tonic clonic, symmetrical generalised seizures lasting < 20 minutes

17
Q

What is the difference between a partial and a generalised seizure?

A

Partial is focal, whereas generalised seizures are across the entire cortex

18
Q

Why can diagnosis of epilepsy in children be difficult?

A
  • Non-epileptic paroxysmal disorders are more common in children
  • Difficulty in explaining (Children are not young adults)
  • Difficulty in interpretation (witness)
  • Difficulty in interpretation and synthesising information(physician
19
Q

What would you want to exclude as causes of seizures in a child who you think has had a febrile convulsion?

A
  • Meningo-encephalitis
  • CNS lesion
  • Epilepsy
  • Trauma
  • Hypoglycaemia
  • Hypocalcaemia
  • Hypomagnasaemia
20
Q

How would you manage a febrile convulsuion if the seizure lasted <5 minutes?

A
  • IV Lorazepam
  • Buccal midazolam
  • PR diazepam
21
Q

How would you approach assessing seizures to try to determine a cause?

A
  • Is the paroxysmal event epileptic in nature?
  • Is it epilepsy?
  • What seizure types are occurring?
  • What is the epilepsy syndrome?
  • What is the etiology?
  • What are the social and educational effects on the child?
22
Q

What is first line management for generalised epilepsy in a child?

A

Sodium valproate

23
Q

How might you investigate a child presenting with recurrent seizures?

A
  • Video recording of event
  • ECG in convulsive seizures
  • Interictal/ ictal EEG
  • MRI Brain: to determine etiology eg. Brain malformations/ brain damage
  • Genetics: idiopathic epilepsies are mostly familial; also single gene disorders eg. Tuberous sclerosis
  • Metabolic tests: esp if associated with developmental delay/ regression
24
Q

What is the first line treatment for partial/focal epilepsies?

A

Carbemazepine

25
Q

What is first line treatment for absence seizures?

A

Ethosuximide

26
Q

What would you use as first-line treatment for myoclinic seizures in children?

A

Sodium valproate

27
Q

What are second line treatment options for generalised seizures?

A
  • Lamotrigine
  • Carbemazepine
28
Q

What are second line treatments for absence seizures?

A

Sodium valproate

29
Q

What are second line treatments for myoclonic seizures?

A
  • Leviteracetam
  • Topiromate
30
Q

What are second line treatments for partial seizures?

A
  • Sodium valproate
  • Oxcarbazepine
31
Q

What options are available for drug-resistant epilepsy?

A
  • Ketogenic diet
  • Vagus nerve stimulation
32
Q

What are infantile spasms?

A

Clusters of head nodding and arm jerks, every 3-30 seconds

33
Q

How would you treat infantile spasms?

A

Vigabatrin