Neurology Flashcards
Most common complication from perinatal asphyxia
Renal failure (40-70%)
When to initiate therapeutic hypothermia
Within 6 hours- reperfusion injury stage
NNT to prevent neuro disability for TH
<10
What stage of encephalopathy do you cool for?
MODERATE
SEVERE
MILD IS NOT PROVEN!!
Gold standard for seizure detection
Continuous EEG- at least 24 hours
aEEG useful adjunct or alternative
Monitoring for seizures is recommended by AAP, ACNS
25-40% of babies cooled for HIE have seizures in first 72 hrs of birth
HIE typical patterns of injury on MRI
Basal ganglia and thalami (relay station)
Posterior limb of the internal capsule (dense motor pathway through BGT)
Brain stem (preterm or severe)
Watershed- cortex and white matter
Most predictive of severity of motor in patient with HIE
Severity of basal ganglia and thalamus injury
Most predictive of walking at age 2 in HIE MRI
PLIC
Most common type of stroke
Arterial ischemic stroke (80%)
Seizures are most common presenting sign (>75%) - DO NOT PRESENT WITH HEMIPLEGIA but can have hemiplegia on contralateral side as sequelae
Vein of Galen
High output heart failure
Subgaleal bleed at risk for brain injury- how?
Size of bleed leads to ischemic brain injury
Major cause of neuro developmental impairment in preterm infants
IVH
Classification of IVH
Severity of outcome of IVH related to
Grade of hemorrhage
Unilateral/bilateral, midline shift
Extent of parenchyma involvement
Most common outcome from IVH/PVL
Spastic diplegia- hypertonia with spasticity
LE>UE
PVL outcomes
Increasing rates of disability with severity of white matter abnormalities
Pupillary response
CN 2,3
28 weeks
Extra-ocular movements
CN 2, 3, 4, 6
Fix/follow at 34 weeks
Disconjugate if not fixing
Dolls eyes
Facial grimace
CN 5 & 7
Strength, symmetry
Suck
Cranial nerves 5, 7, 12
Swallow
CN 9, 10
MORO
3 components:
1. ABDUCTION - arms/hands spread open (25-28 wks)
2. ADDUCTION- arms/shoulders “hugging/embracing” (33/34 wks)
3. Audible cry- may not always be elicited
Absent/incomplete- upper motor neuron
Asymmetric- consider brachial plexus injury
True or false?
Neonatal seizures are not reliably diagnosed by clinical observation alone
TRUE
True/false
Most neonatal seizures are symptomatic of acute brain illness (~80%)
TRUE!!
Most common:
- HIE (~50% in US)
- stroke/hemorrhage
- infection
- malformations
- electrolytes/hypoglycemia
Highest yield test for neonatal seizure
BRAIN MRI- ASAP
~90% will have diagnosis apparent on MRI
Prognosis following neonatal seizures
Etiology is the single most important prognostic factor
Higher seizure burden is associated with increased risk of poor outcome
Burst suppression
POOR prognosis
Persistent burst suppression at 72 hours in HIE carries a very poor prognosis
Neonatal onset epilepsies with burst suppression are typically ominous
MC localization of neonatal hypotonia
BRAIN
ANTERIOR HORN CELL- SMA
peripheral nerve- Riley-day
Peripheral=rare
MC cause of hydrocephalus in neonates
IVH
post hemorrhagic hydrocephalus - MC cause of obstructive and communicating hydrocephalus
Leads to significant increase in cerebral blood flow
Hypoglycemia
Hypercapnia
Anemia
Leads to decrease in cerebral blood flow
Polycythemia
Hypotension
Hypocarbia
When fetus becomes responsive to auditory information
26 weeks
Immature auditory system functional 25-29, complete by 30 weeks
Compared to UA, UV blood gas
Higher pH, lower pCO2, higher pO2
V (high, low, high)
Therapeutic hypothermia alters first or second energy failure most?
SECOND
When do you initiate cooling?
Latent phase- 1-6 hrs
Most common cause of CP in term neonate
HIE
HUS findings in HIE
Serial HUS over first 4 days most helpful
Edema peak=24 hrs
Single HUS in first week is normal in 50% HIE
Doppler US for resistive index (or pulsatility index) increases sensitivity and specificity
Deficits from stroke
Motor- depends on location
Learning/behavior
Epilepsy
IVH epidemiology
Highest risk <29 weeks, <1500g
Grade 3/4 highest among youngest and smallest
Risk factors for IVH
Gestational age- younger= higher risk
Lack of antenatal steroids
Lack of exposure to mag sulfate
Birth outside an experienced center/need for transport
CV and respiratory compromise at birth-1st week
Hypercapnia —> cerebral vasodilation
Hypernatremia (>150)
CP from PVL
SPASTIC DIPLEGIA
Neonate with PVL
oligodendrocytes affected
HIE leads to decreased…
phosphocreatinine
HIE type of CP
spastic quadriplegia
Learning and behavior issues in HIE after TH are indicative of injuries in what area?
Watershed