Neurology

Question 1

Glioblastoma multiforme – gross appearance and histological characteristic

Answer 1

0 GROSSLY
- VARIEGATED Appearance, with SOME Areas showing GREY-WHITE Appearance

• Others are YELLOW + SOFT w/ FOCI of Haemorrhages AND Necrosis
• Surrounding BRAIN TISSUE is DISTORTED / INFILTRATED by YELLOW Tumour Tissue

0 MICROSCOPICALLY
- HIGHLY Anaplastic

• Variation = Fusiform Cells / Small Poorly-Differentiated Round Cells / Pleomorphic Cells / Giant Cells
• Some Areas of TUMOUR NECROSIS where Tumour Cells FORM PSEUDOPALISADING
• Microvascular Endothelial Proliferation is MARKED

Question 2

Bacterial meningitis gross and histology

Answer 2

DEFINITION = ACUTE Purulent Inflammation of PIA MATER, ARACHNOID + CSF enclosed BTW them

0 GROSS
- Subarachnoid Space is FILLED WITH PUS, so CSF becomes PURULENT

• SWOLLEN Meninges

0 HISTO
- OEDEMATOUS Meninges

• ABUNDANT Neutrophils in Subarachnoid Space AND Meninges
• UNDERLYING Brain Tissue shows PERIVASCULAR + PERICELLULAR OEDEMA