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Pharmakologie > Neuroleptika > Flashcards

Neuroleptika Flashcards

1
Q

LEVOMEPROMAZIN

A
  1. Gen

H1-Antagonismus (Phenotiazine)

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2
Q

FLUPHENAZIN

A
  1. Gen
    Extrapyramidale Symptome (15-30%)
    H1-Antagonismus (Phenotiazine)
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3
Q

CHLORPROTHIXEN

A
  1. Gen
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4
Q

ZUCLOPENTHIXOL

A
  1. Gen
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5
Q

FLUPENTHIXOL

A
  1. Gen
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6
Q

HALOPERIDOL

A 
1. Gen
Block +, keine Wirkung -
D2 +++, Alpha +, D4 -,    5-HT2 -, M -, H1 -
Tourette, Erbrechen
Extrapyramidale Symptome (15-30%)
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7
Q

DROPERIDOL

A
  1. Gen

Schizophrenia, nausea

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8
Q

TIAPRID

A
  1. Gen
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9
Q

AMISULPRID

A
  1. Gen
    UeW: D2-Antagonismus → Hyperprolactinämie
    – Gynäkomastie – Männer
    – Vermindertes Libido – Männer
    – Amenorrhö (Ausbleiben der Menstruation)
    – Galaktorrhö (Milchfluss) – Frauen
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10
Q

SULPIRID

A
  1. Gen
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11
Q

OLANZAPIN

A 
2. Gen
Block +, keine Wirkung -
D2 +
D4 -
Alpha +
5-HT2 ++
M +
H1 +
Manische Episoden bei
bipolaren Störungen
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12
Q

QUETIAPIN

A 
2. Gen
Block +, keine Wirkung -
D2 +
D4 -
Alpha +
5-HT2 ++
M +
H1 +
Manische Episoden bei
bipolaren Störungen
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13
Q

CLOZAPIN

A 
2. Gen
Block +, keine Wirkung -
D2 -
D4 ++
Alpha ++
5-HT2 ++
M ++
H1 +
UeW: -Orthostatische Hypotonie  
-Ejakulationsprobleme
-Agranulozytose (1-2%)
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14
Q

RISPERIDON

A
  1. Gen
    Schizophrenia, bipolar disorder
Block +, keine Wirkung -
D2 ++
D4 -
Alpha +
5-HT2 ++
M +
H1 +
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15
Q

ZIPRASIDON

A 
2. Gen
Block +, keine Wirkung -
D2 ++
D4 -
Alpha ++
5-HT2 ++
M -
H1 +
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16
Q

PALIPERIDON

A
  1. Gen
17
Q

SERTINDOL

A
  1. Gen

D2, a, 5-HT2

18
Q

ARIPIPRAZOL

A 
2. Gen
Sonstiges
Block +, keine Wirkung -
D2 +
D4 +
Alpha +
5-HT2 ++
M -
H1 +
19
Q

Neuroleptika

A

Motorische Unerwünschte Wirkungen Antagonismus
• Extrapyramidale Symptome (15-30%)
• Tardive Dyskinesie (15-20%)
• Malignesneuroleptisches Syndrom (0,02-0,05%)

20
Q

PK

A 
• Resorption
– Bioverfügbarkeit nur 60% wegen First-Pass-Metabolismus
 • Verteilung
– Über 90% Plasmaproteinbindung
• Metabolismus
– Ausgeprägt
– Über CYP-Enzyme
• Ausscheidung 
– Unterschiedlich

Pharmakologie (47 decks)

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