neurogenesis Flashcards
thymidine
precursor of chromosomal DNA, needed for neurogenesis
new cells in ventricles
Number of cells initially increases, then decrease due to migration away to olfactory bulb after maturation
Via. rostral migratory stream
new cells in olfactory bulb
In mitral & granular layer: increase remains constant
new cells in cerebellum
New cells don’t survive because lack of synaptic input
MASH1
proneural protein, cell fate
intermediate progenitor cell + MASH1 = oligodendrocyte
nestin
type 4 intermediate filament protein
expressed in RLG cells
nestin = potential to become neurons, but this is triggered by other things
vimentin
type 3 intermediate filament protein
- mesenchymal cells
GFAP
glia fibrillary acidic protein expressed on glia (most astrocytes)
DCX
microtubule associated protein
if present: most likely to become a neuron
- neural precursor cells & immature neurons
neuN
neuronal nuclear antigen
- marker for mature neurons
Calbindin
calcium binding proteins
- marker for mature neurons
Sox 2
transcription factor - key roles n mammalian development
(radial glia like cell)
MCM2
minichromosome maintenance complex component 2
marker of progenitor cells & neuroblasts
neurogenesis rate per year
1.75%
what factor dictates survival of nascent neurons?
degree of synaptic input it receives
(local trophic factors & support from glia also important but not necessary)
