Neurodegenerative diseases

Question 1

what is Transmissible Spongeiform Encephalopathies mean? define word by word

Answer 1

First, it’s a prion: it’s a protein infection

transmissible means that it’s contagious

spongeiform meaning it creates holes in the brain like sponges.

and encephalopathies just means brain.

Question 2

How can you get PrpSc

Answer 2

it can be from a sporadic mutation

it can acquired by eating, from medical procedure (iatrogenic) or a variant

it can la familia

and it will start to aggregate and cause death

Question 3

TSE progression

Answer 3

MAIN point: theres really no cure.

death, physical issues and mental.

Question 4

Parkinson’s disease is a

Answer 4

degeneration of of the substantia nigra

Loss of dopamine in niagrastriatal pathways (in Basal ganglia).

Question 5

In parkinson’s disease, what does the loss of dopamine do

Answer 5

it leads to dense circular alpha synuclein proteins that breaksdown the N-S path. which unables to send dopamine to amplif the path.

Question 6

What is the pharmaceutical treatment (for primary functions) for parkinsons

Answer 6

You simply give dopamine (L- dopa)

Question 7

What are the surgical treatments for parkinsons

Answer 7

1) fetal tissue transplant in N-S
2) Pallidotomies: you make lesion in areas that inhibits S.T.N and G.P.I. (globus pallidus internal).
3) Deep stimili: placing electrode to stimulate areas like mention above.

Question 8

What is the viral treatment way for parkinsons

Answer 8

you inject a modified virus in the STN